Searching for new natural inhibitors of acetylcholinesterase enzyme

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dc.authoridYasemin Camadan / 0000-0002-9000-7761en_US
dc.contributor.authorCamadan, Yasemin
dc.contributor.authorAkkemik, Ebru
dc.date.accessioned2023-01-03T08:41:10Z
dc.date.available2023-01-03T08:41:10Z
dc.date.issued2022
dc.departmentAÇÜ, Sağlık Hizmetleri Meslek Yüksekokulu, Eczane Hizmetleri Bölümüen_US
dc.description.abstractAcetylcholinesterase enzyme (AChE) is the enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine to choline. Inhibitors of this enzyme (AChE-i) are used to treat Alzheimer's, a neurodegenerative disease. Due to the side effects of the drugs used, there has been an increased interest in investigating the inhibitory potentials of natural products which are presumed to have fewer side effects. For this purpose, the inhibitory effects of highland honey, chestnut honey, royal jelly and the seeds of peach, cherry, plum and apricot on human erythrocyte AChE enzyme was investigated in vitro in the present study. Extracts of the seeds and bee products were prepared in ethanol solvent. In order to determine the inhibitory effect of the extracts, the inhibition concentration (IC50) and Ki values which cause 50% inhibition of the enzyme were calculated using the Ellman method. It was found that among the natural product extracts studied, peach seed had the highest inhibition level (IC50 value 0.05708 mg/ml). IC50 values of highland honey, royal jelly, plum seed and apricot seed were determined as 0.2555 (mg/mL), 0.300 (mg/mL), 0.7049 (mg/mL) and 0.4544 (mg/mL) respectively.
dc.identifier.citationCamadan, Y., & Akkemik, E. (2022). Searching for New Natural Inhibitors of Acetylcholinesterase Enzyme. Cumhuriyet Science Journal, 43(1), 66–71.en_US
dc.identifier.doi10.17776/csj.983869
dc.identifier.endpage71en_US
dc.identifier.issn2587-2680
dc.identifier.issn2587-246X
dc.identifier.issue1en_US
dc.identifier.startpage66en_US
dc.identifier.urihttps://doi.org/10.17776/csj.983869
dc.identifier.urihttps://hdl.handle.net/11494/4386
dc.identifier.volume43en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorCamadan, Yasemin
dc.language.isoenen_US
dc.publisherCumhuriyet Üniversitesien_US
dc.relation.ispartofCumhuriyet Science Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlzheimeren_US
dc.subjectAChEen_US
dc.subjectInhibitionen_US
dc.subjectBee productsen_US
dc.subjectFruit seedsen_US
dc.titleSearching for new natural inhibitors of acetylcholinesterase enzymeen_US
dc.typeArticle

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