Antimicrobial and antiurease activities of newly synthesized morpholine derivatives containing an azole nucleus

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dc.authorid0000-0002-8444-2011en_US
dc.contributor.authorBektaş, Hakan
dc.contributor.authorCeylan, Şule
dc.contributor.authorDemirbaş, Neslihan
dc.contributor.authorAlpay Karaoğlu, Şengül
dc.contributor.authorSökmen, Bahar Bilgin
dc.date.accessioned2021-12-08T06:24:12Z
dc.date.available2021-12-08T06:24:12Z
dc.date.issued2013
dc.departmentAÇÜ, Orman Fakültesi, Orman Endüstri Mühendisliği Bölümüen_US
dc.description.abstract2-[6-(Morpholin-4-yl)pyridin-3-ylamino]acetohydrazide (4) was obtained starting from 6-morpholin-4-ylpyridin-3-amine (2) via the formation of ester (3) and then converted to the corresponding Schiff bases (5, 6) with the reaction with aromatic aldehydes. The carbothioamide (9), obtained from the reaction of hydrazide with phenylisothiocyanate, was converted to the corresponding 1,2,4-triazole (11) and 1,3,4-thiadiazole (12) derivatives by the treatment with NaOH or H2SO4, respectively. The cyclocondenzation of 9 with 4-chlorophenacyl bromide or ethyl bromoacetate produced the corresponding 1,3-thiazole (10) or 1,3-thiazolidine derivatives (13), respectively. Antimicrobial and antiurease activities of newly synthesized compounds were investigated. Some of them were found to be active on M. smegmatis, and they displayed activity toward C. albicans and S. cerevisiae in high concentration. Compound 10 proved to be the most potent showing an enzyme inhibition activity with an IC50 = 2.37 +/- A 0.19 mu M.
dc.identifier.citationBektaş, H., Ceylan, Ş., Demirbaş, N., Alpay-Karaoğlu, Ş., & Sökmen, B. B. (2013). Antimicrobial and antiurease activities of newly synthesized morpholine derivatives containing an azole nucleus. Medicinal Chemistry Research, 22(8), 3629-3639.en_US
dc.identifier.doi10.1007/s00044-012-0318-1
dc.identifier.endpage3939en_US
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage3629en_US
dc.identifier.urihttps://hdl.handle.net/11494/3592
dc.identifier.volume22en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSpringer Birkhauseren_US
dc.relation.ispartofMedicinal Chemistry Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMorpholineen_US
dc.subject1,2,4-Triazoleen_US
dc.subject1,3,4-Oxadiazoleen_US
dc.subjectMannich baseen_US
dc.subjectAntimicrobial activityen_US
dc.subjectAntiurease activityen_US
dc.titleAntimicrobial and antiurease activities of newly synthesized morpholine derivatives containing an azole nucleusen_US
dc.typeArticle

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