Protective effects of Echinacea purpurea in an acetic acid induced rat model of colitis

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dc.authorid0000-0003-2779-6478en_US
dc.contributor.authorBayramoğlu, Gökhan
dc.contributor.authorŞentürk, Hakan
dc.contributor.authorDokumacıoğlu, Ali
dc.contributor.authorAral, Erinç
dc.contributor.authorKanbak, Güngör
dc.contributor.authorİnal, Mine
dc.contributor.authorOğlakçı, Ayşegül
dc.date.accessioned2022-07-21T13:01:17Z
dc.date.available2022-07-21T13:01:17Z
dc.date.issued2012
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractIn order to investigate putative protective effects of Echinacea purpurea on colonic inflammation, we determined Adenosine deaminase (ADA) and superoxide dismutase (SOD) activities, malondialdehyde (MDA) levels and protein carbonyl contents were determined in colonic tissues of rats in the colitis and colitis plus Echinacea purpurea (at different doses 50,100 mg/kg) given rats. Besides, histopathology of colon tissues were evaluated. In the Echinacea treatment groups (50 and 100 mg/kg doses) ADA activities were significantly decreased as compared to acetic acid group, but there was no statistically significant between two treatment groups (p>0.05). Echinacea treatment also was decreased MDA levels at two doses according to colitis group (p<0.05). There was no statistically significant between two treatment groups (p>0.05). Slightly decreased protein carbonyl contents and elevated SOD activities were shown in the two Echinacea therapy groups as compared to acetic acid induced colitis group. But these were not statistically significant (p>0.05). Similar observations were recorded for these parameters in the extracts of colonic tissue specimens. The results revealed that pretreatment to colitic rats with Echinacea purpurea at doses of 50 and 100 mg/kg, partially attenuated the colonic damage induced by acetic acid. In conclusion, the preventive effects of Echinacea purpurea in the acetic acid model of rat colitis is probably related to its antioxidant properties, due to its flavonoid content.
dc.identifier.citationSenturk, H., Bayramoglu, G., Dokumacioglu, A., Erinc, A. R. A. L., Kanbak, G., Mine, İ. N. A. L., & Oglakci, A. (2012). Protective effects of Echinacea purpurea in an acetic acid induced rat model of colitis. Biyolojik Çeşitlilik ve Koruma, 5(2), 59-65.en_US
dc.identifier.endpage65en_US
dc.identifier.issue2en_US
dc.identifier.startpage59en_US
dc.identifier.urihttps://hdl.handle.net/11494/3929
dc.identifier.volume5en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorBayramoğlu, Gökhan
dc.language.isoenen_US
dc.publisherBiological Diversity and Conservationen_US
dc.relation.ispartofBiological Diversity and Conservation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEchinacea purpureaen_US
dc.subjectColitisen_US
dc.subjectSuperoxide dismutaseen_US
dc.subjectMalondialdehydeen_US
dc.subjectAdenosine deaminaseen_US
dc.titleProtective effects of Echinacea purpurea in an acetic acid induced rat model of colitisen_US
dc.typeArticle

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