HPLC method for the analysis of chlorogenic acid of Viburnum tinus L. and Viburnum orientale Pallas

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dc.contributor.authorÖzbilgin, Serkan
dc.contributor.authorErgene, Burçin
dc.contributor.authorAltun, Mehmet Levent
dc.contributor.authorSever Yilmaz, Betül
dc.contributor.authorSaltan, Gülçin
dc.contributor.authorYüksel, Emrah
dc.date.accessioned2025-07-03T10:15:08Z
dc.date.available2025-07-03T10:15:08Z
dc.date.issued2015
dc.departmentAÇÜ
dc.description.abstractA simple and sensitive method for separation and determination of chlorogenic acid has been developed. Chlorogenic acid was separated using a Supelcosil LC 18 column (250 x 4.6 mm, 5 μm) by gradient elution at the flow rate of 1.2 mL/min. The composition of mobile phase consisted of ophosphoric acid, bidistilled water (0.2%) and acetonitrile. Spectrophotometric detection was carried out at 330 nm. The linear range of detection for chlorogenic acid was between 0.7237-500 μg/mL. The method described was suitable for the determination of chlorogenic acid in the leaves, branches and fruits of Viburnum tinus L. and Viburnum orientale Pallas. It was observed that V.orientale fruit sample has the highest chlorogenic acid content (0.5069%), while V.tinus branches (0.0141%) have the lowest chlorogenic acid content as w/w (%) in our case. This study is the first application of High Performance Liquid Chromatography (HPLC) method to the determination of chlorogenic acid content of V. tinus and V. orientale in Turkey.
dc.identifier.doi10.5505/tjps.2015.54264
dc.identifier.endpage236
dc.identifier.issn1304530X
dc.identifier.issue2
dc.identifier.scopus2-s2.0-84940506747
dc.identifier.scopusqualityQ2
dc.identifier.startpage231
dc.identifier.urihttps://hdl.handle.net/11494/5655
dc.identifier.volume12
dc.indekslendigikaynakScopus
dc.institutionauthorYüksel, Emrah
dc.language.isoen
dc.publisherTurkish Pharmacists Association
dc.relation.ispartofTurkish Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChlorogenic acid
dc.subjectHPLC
dc.subjectViburnum orientale
dc.subjectViburnum tinus
dc.titleHPLC method for the analysis of chlorogenic acid of Viburnum tinus L. and Viburnum orientale Pallas
dc.title.alternativeViburnum tinus L. ve Viburnum orientale pallas’de YPSK ile klorojenik asit analizi
dc.typeArticle

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