Synthesis of novel Schiff bases using green chemistry techniques; antimicrobial, antioxidant, antiurease activity screening and molecular docking studies

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dc.authorid0000-0002-4789-7180en_US
dc.authorid0000-0001-8827-8557en_US
dc.contributor.authorMermer, Arif
dc.contributor.authorDemirbaş, Neslihan
dc.contributor.authorUslu, Harun
dc.contributor.authorDemirbaş, Ahmet
dc.contributor.authorCeylan, Şule
dc.contributor.authorŞirin, Yakup
dc.date.accessioned2020-11-20T12:49:46Z
dc.date.available2020-11-20T12:49:46Z
dc.date.issued2019
dc.departmentAÇÜ, Orman Fakültesien_US
dc.description.abstractSchiff base derivatives were synthesized in this study via conventional, microwave irradiation and ultrasound sonication methods. Optimization conditions were examined for several parameter such as solvent, reaction time and yield. After determining the optimization conditions, the compounds were synthesized by using ultrasound sonication. The structures of the synthesized compounds were examined by spectral data, and the antiurease, antioxidant and antimicrobial activities of the Schiff bases derivatives were investigated due to the imine group (-C=N-) and promising results were obtained. The enzyme inhibitory potentials of these compounds were further validated through molecular docking studies. Also, In Silico ADME prediction studies were calculated for compounds.
dc.identifier.citationMermer, A., Demirbaş, N., Uslu, H., Demirbaş, A., Ceylan, S., & Şirin, Y. (2019). Synthesis of novel Schiff bases using green chemistry techniques; antimicrobial, antioxidant, antiurease activity screening and molecular docking studies. Journal of Molecular Structure, 1181, 412-422.en_US
dc.identifier.doi10.1016/j.molstruc.2018.12.114
dc.identifier.endpage422en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage142en_US
dc.identifier.urihttps://hdl.handle.net/11494/2479
dc.identifier.volume1181en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorCeylan, Şule
dc.language.isoenen_US
dc.publisherElsevier Science BVen_US
dc.relation.ispartofjournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUltrasound sonicationen_US
dc.subjectMicrowave irradiationen_US
dc.subjectBiological activityen_US
dc.subjectADME predictionen_US
dc.titleSynthesis of novel Schiff bases using green chemistry techniques; antimicrobial, antioxidant, antiurease activity screening and molecular docking studiesen_US
dc.typeArticle

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