A cooperative computational and experimental investigation on electrochemical behavior of metoprolol and its voltammetric determination

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dc.authorid0000-0002-3087-5145en_US
dc.contributor.authorZorluoğlu, Seraceddin Levent
dc.contributor.authorTaşdemir, İbrahim Hüdai
dc.contributor.authorEce, Abdulilah
dc.contributor.authorKılıç, Esma
dc.date.accessioned2021-12-07T12:44:50Z
dc.date.available2021-12-07T12:44:50Z
dc.date.issued2013
dc.departmentAÇÜ, Eğitim Fakültesi, Matematik ve Fen Bilimleri Eğitimi Bölümüen_US
dc.descriptionThis research has been supported by Ankara University Scientific Research Projects Coordination Unit, project No. 11B4240005, 2011.en_US
dc.description.abstractThe electrochemical behavior of metoprolol (MTP) was studied via experimental and computational approaches. Theoretical calculations were performed at the B3LYP/6-31+ G(d)//AM1 level whereas experimental studies were carried out on a hanging mercury drop electrode (HMDE) and glassy carbon electrode (GCE). According to the computational results, both HOMO and LUMO of MTP were located at the phenyl ring. Hence, oxidation and reduction are expected to take place at the phenyl ring. Experimental studies on HMDE were based on reversible reduction at approximately -1.4 V and studies on GCE were based on irreversible oxidation at approximately 0.9 V versus Ag/AgCl (3 mol L-1 KCl) in Britton-Robinson buffer. Voltammetric methods with and without adsorptive stripping modes were developed. Proposed methods were successfully applied to tablet solutions and spiked human serum samples. Results are satisfactory with recovery values between 94.5% and 102.5% and a relative standard deviation lower than 6%.
dc.identifier.citationZorluoğlu, S. L., Taşdemir, İ. H., Ece, A., & Kılıç, E. (2013). A cooperative computational and experimental investigation on electrochemical behavior of metoprolol and its voltammetric determination. Canadian Journal of Chemistry, 91(10), 951-959.en_US
dc.identifier.doi10.1139/cjc-2012-0531
dc.identifier.endpage959en_US
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage951en_US
dc.identifier.urihttps://hdl.handle.net/11494/3590
dc.identifier.volume91en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorZorluoğlu, Seraceddin Levent
dc.language.isoenen_US
dc.publisherCanadian Science Publishingen_US
dc.relation.ispartofCanadian Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdsorptive stripping voltammetryen_US
dc.subjectDFTen_US
dc.subjectElectrochemical behavioren_US
dc.subjectHOMOen_US
dc.subjectLUMOen_US
dc.subjectMetoprololen_US
dc.titleA cooperative computational and experimental investigation on electrochemical behavior of metoprolol and its voltammetric determinationen_US
dc.typeArticle

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