Antimicrobial, antioxidant and antiproliferative activities of novel quinolones

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dc.contributor.authorCeylan, Şule
dc.contributor.authorCebeci, Yıldız Uygun
dc.contributor.authorDemirbaş, Neslihan
dc.contributor.authorBatur, Özge Özşen
dc.contributor.authorÖzakpınar, Özlem Bingöl
dc.date.accessioned2020-10-19T06:17:25Z
dc.date.available2020-10-19T06:17:25Z
dc.date.issued2020
dc.departmentAÇÜ, Orman Fakültesien_US
dc.description.abstractThe compound (2) formed by esterification of dimethyl morpholine (1) was converted to acetohydrazide (3). Subsequently Schiff bases (4 a-d) and carboxy(thio)amide derivatives (5 a-e) were synthesized. Then 1,2,4-triazole (6 a-e), thia(oxa)zolidine (7 c,e) and thia(oxa)zol (8 c,e) derivatives were obtained by ring closure from carboxy(thio)amides. Mannich bases, which are containing quinolone were synthesized from 1,2,4-triazoles. The structures of newly synthesized compounds were illuminated by spectroscopic methods. Their antimicrobial (MIC method), antioxidant (DPPH, FRAP, and CUPRAC methods), and anticancer activities (MTT method) were examined. Results showed that most of the compounds exhibited good antimicrobial (<0.03-31.25 mu g/mL with MIC values) and antioxidant activities (IC50=0.001-0.004 with DPPH values). Also, some of the compounds have been found to have antiproliferative effects on the prostate (PC-3), liver (Hep3B), and breast (MCF-7) human cancer cells, and also these compounds did not have a cytotoxic effect on a normal cell.
dc.description.sponsorshipThis work was supported by Artvin Coruh University, BAP (2016.F11.02.06), Turkey.en_US
dc.identifier.citationCeylan, Ş., Cebeci, Y. U., Demirbaş, N., Batur, Ö. Ö., & Özakpınar, Ö. B. (2020). Antimicrobial, Antioxidant and Antiproliferative Activities of Novel Quinolones. ChemistrySelect, 5(36), 11340-11346.en_US
dc.identifier.doi10.1002/slct.202002779
dc.identifier.endpage11346en_US
dc.identifier.issue36en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage11340en_US
dc.identifier.urihttps://hdl.handle.net/11494/2300
dc.identifier.volume5en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorCeylan, Şule
dc.language.isoenen_US
dc.publisherWiley-VCH GmbHen_US
dc.relation.ispartofChemistrySelect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject1; 2; 4-triazoleen_US
dc.subjectQuinoloneen_US
dc.subjectAntioxidanten_US
dc.subjectAntimicrobialen_US
dc.subjectAnticancer activityen_US
dc.titleAntimicrobial, antioxidant and antiproliferative activities of novel quinolonesen_US
dc.typeArticle

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