Fluoroquinolone-triazole hybrid molecules: A comparative analysis of conventional and green synthetic methods, and evaluation of their biological activities

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dc.contributor.authorAyvaz, Aslıhan
dc.contributor.authorDemirbaş, Neslihan
dc.contributor.authorDemirbaş, Ahmet
dc.contributor.authorCeylan, Şule
dc.contributor.authorÇolak, Nesrin
dc.contributor.authorAyaz, Faik Ahmet
dc.contributor.authorKılıç, Ali Osman
dc.contributor.authorDurukan, İnci
dc.contributor.authorKara, Yakup
dc.date.accessioned2025-10-02T11:25:35Z
dc.date.available2025-10-02T11:25:35Z
dc.date.issued2025
dc.departmentAÇÜ, Orman Fakültesi, Orman Endüstri Mühendisliği Bölümü
dc.description.abstractIn this study, a series of 1,2,4-triazole derivatives was initially synthesized and subsequently incorporated into the fluoroquinolone scaffold via Mannich-type reactions. The reactions were conducted using conventional heating, ultrasound-assisted synthesis, and microwave irradiation techniques to determine the optimal reaction conditions. FTIR, NMR, and mass spectrometry analyses characterized the structures of the resulting compounds. Furthermore, the synthesized derivatives were assessed for their antimicrobial and antioxidant properties. Their inhibitory activities against key enzymes, urease, α-amylase, α-glucosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase, were also investigated, with several compounds exhibiting noteworthy bioactivity. Nearly all the synthesized hybrid compounds exhibited minimum inhibitory concentration (MIC) values comparable to standard antibacterial agents such as norfloxacin and ciprofloxacin. Except for 4-arylideneamino-1,2,4-triazole-3-one derivatives, all tested compounds demonstrated notable anti-urease activity. Furthermore, several newly synthesized molecules showed promising inhibitory effects against α-amylase and α-glucosidase enzymes.
dc.identifier.doi10.1002/slct.202501312
dc.identifier.issn23656549
dc.identifier.issue37
dc.identifier.scopus2-s2.0-105017094197
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://hdl.handle.net/11494/5962
dc.identifier.volume10
dc.indekslendigikaynakScopus
dc.institutionauthorCeylan, Şule
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofChemistrySelect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAntimicrobial
dc.subjectAntioxidant capacity
dc.subjectEnzyme inhibition
dc.subjectGreen techniques
dc.subjectQuinolone
dc.subjectTriazole
dc.titleFluoroquinolone-triazole hybrid molecules: A comparative analysis of conventional and green synthetic methods, and evaluation of their biological activities
dc.typeArticle

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