Investigation of the properties of 1,2,4-triazole-3-thione schiff base derivatives by urease inhibition as therapeutic or agrochemical candidate molecules
Yükleniyor...
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
John Wiley and Sons Inc
Erişim Hakkı
info:eu-repo/semantics/embargoedAccess
Özet
With the production of bacterial urease, bacteria can provide the best conditions for colonization and survival of the stomach in acidic environment. Due to this reproductive ability, H. pylori can cause various diseases such as cancer, urinary tract infections, and peptic ulcer in human metabolism. Consequently, the discovery of substances that can inhibit urease activity holds great promise for treating certain diseases. In this study, Schiff base derivatives of 1,2,4-triazole-3-thione were synthesized in good to excellent yields. The structures of the obtained compounds were elucidated using spectroscopic techniques, such as FT-IR, ¹H-NMR and ¹³C-NMR. The urease inhibitory activities of the obtained products were evaluated against the reference inhibitor thiourea. Out of these compounds, compound 6 c exhibited the highest inhibitory effectiveness, with an IC?? value of 0.0109 ?M against refenrence inhibitor (IC??=11 ?M). Kinetic studies revealed that compound 6 c acts as a non-competitive inhibitor. According to the results of the docking studies, compound 6 c exhibited the highest binding affinity (with the lowest ?G value as ?8.4 kcal/mol) and efficiently interacted with the enzyme as a potent inhibitor among all the molecules examined in the study.
Açıklama
Anahtar Kelimeler
1,2,4-Triazole-3-Thione, ADME, Docking, Inhibition, Urease
Kaynak
ChemistrySelect
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
9
Sayı
26
