The efficacy of carvacrol on renal damage in rats with acute pancreatitis

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dc.contributor.authorHsseinigouzdagani, Mirkhalil
dc.contributor.authorGeyikoğlu, Fatime
dc.contributor.authorÇolak, Suat
dc.contributor.authorTürkez, Hasan
dc.contributor.authorBakır, Tülay Özhan
dc.contributor.authorBakır, Murat
dc.date.accessioned2021-10-25T12:52:11Z
dc.date.available2021-10-25T12:52:11Z
dc.date.issued2014
dc.departmentAÇÜen_US
dc.descriptionThis investigation was supported by Ataturk University (BAP-2012/167).en_US
dc.description.abstractThe carvacrol is thought to promote optimal health via its antioxidant and free radical scavenging effects. The aim of our present study was to investigate the efficacy of carvacrol on the development of kidney injury in acute pancreatitis model (AP) induced by cerulein and to explore the underlying mechanism. The rats were randomised into groups to receive (I) no therapy; (II.) 50 ?g/kg cerulein at 1-h intervals by four intraperitonally injection (i.p.); (III) 50, 100 and 200 mg/kg carvacrol by one i.p.; and (IV) cerulein+carvacrol after 2 h of cerulein injection. 12 h later, serum was provided to assess the blood urea nitrogen (BUN), creatinine (CRE) and uric acid (UA) values. Also, renal tissues were obtained for histological and biochemical measurements. Kidney oxidative stress markers were evaluated by changes in the amount of lipid peroxides measured as malondialdehyde (MDA) and changes in tissue antioxidant enzyme levels, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-PX). Histopathological examination was performed using scoring systems. We found that the increasing doses of carvacrol decreased pancreatitis-induced MDA levels. Moreover, the renal SOD, CAT and GSH-Px activities in the AP+carvacrol group were higher than that of the rats in the AP group. In the treatment groups, the BUN, CRE and UA were reduced. Besides, necrosis, coagulation and inflammation in the kidney were alleviated (p < 0.05). Finally, the magnitude of the protective effect on kidney is certain, and 200 mg/kg carvacrol is an effective theraphy for oxidative stress caused by AP
dc.identifier.citationHsseinigouzdagani, M., Geyikoglu, F., Çolak, S., Türkez, H., Bakir, T. O., & Bakir, M. (2014). The Efficacy of Carvacrol on Renal Damage in Rats with Acute Pancreatitis. Journal of Essential Oil Bearing Plants, 17(5), 847-858.en_US
dc.identifier.doi10.1080/0972060X.2014.904756
dc.identifier.endpage858en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage847en_US
dc.identifier.urihttps://hdl.handle.net/11494/3540
dc.identifier.volume17en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÇolak, Suat
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofJournal Of Essential Oil Bearing Plants
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExperimental acute pancreatitisen_US
dc.subjectRenal damageen_US
dc.subjectCarvacrolen_US
dc.subjectAntioxidanten_US
dc.subjectHistologyen_US
dc.titleThe efficacy of carvacrol on renal damage in rats with acute pancreatitisen_US
dc.typeArticle

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