Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols including natural products

Basit Öğe Kaydı
dc.contributor.authorBalaydın, Halis Türker
dc.contributor.authorSoyut, Hakan
dc.contributor.authorEkinci, Deniz
dc.contributor.authorGöksu, Süleyman
dc.contributor.authorBeydemir, Şükrü
dc.contributor.authorMenzek, Abdullah
dc.contributor.authorŞahin, Ertan
dc.date.accessioned2022-02-09T07:09:29Z
dc.date.available2022-02-09T07:09:29Z
dc.date.issued2012
dc.departmentAÇÜ, Eğitim Fakültesi, Temel Eğitim Bölümüen_US
dc.description.abstract(2-Bromo-3,4-dimethoxyphenyl) (3,4-dimethoxyphenyl) methanone (10) and its derivatives with Br, one dibromide and isomeric three tribromides, were synthesized. Demethylation of these compounds afforded a series of new bromophenols. Inhibition of human cytosolic carbonic anhydrase II (hCA II) isozyme by these new bromophenols and naturally occurring 3,4,6-tribromo-5-(2,5-dibromo-3,4-dihydroxybenzyl) benzene-1,2-diol (3), and 5,5'-methylenebis(3,4,6-tribromo-benzene-1,2-diol) (4) was investigated. The synthesized compounds showed carbonic anhydrase inhibitory capacities with IC50 values in the range of 0.7-372 mu M against hCA II. Some bromophenols investigated here showed effective hCA II inhibitory activity and might be used as leads for generating novel carbonic anhydrase inhibitors which are valuable drug candidates for the treatment of glaucoma, epilepsy, gastric and duodenal ulcers, neurological disorders, or osteoporosis.
dc.identifier.citationBalaydın, H. T., Soyut, H., Ekinci, D., Göksu, S., Beydemir, Ş., Menzek, A., & Şahin, E. (2012). Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols including natural products. Journal of enzyme inhibition and medicinal chemistry, 27(1), 43-50.en_US
dc.identifier.doi10.3109/14756366.2011.574131
dc.identifier.endpage50en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage43en_US
dc.identifier.urihttps://hdl.handle.net/11494/3713
dc.identifier.volume27en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBalaydin, Halis Türker
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBromophenolsen_US
dc.subjectDiphenylmethaneen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectGlaucomaen_US
dc.subjectEnzyme inhibitionen_US
dc.titleSynthesis and carbonic anhydrase inhibitory properties of novel bromophenols including natural productsen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
halis_turker_balaydin.pdf
Boyut:
1.03 MB
Biçim:
Adobe Portable Document Format
Açıklama:
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Temel Eğitim Bölümü Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu