Synthesis and in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes activity of aldehyde and schiff base substituted cobalt (II), copper (II), and zinc (II) phthalocyanines

Basit Öğe Kaydı
dc.authorid0000-0003-1234-2721en_US
dc.authorid0000-0002-0362-9387en_US
dc.authorid0000-0002-1426-5857en_US
dc.authorid0000-0003-2625-2815en_US
dc.authorid0000-0002-7347-4018en_US
dc.contributor.authorYalazan, Halise
dc.contributor.authorKamiloğlu, Ayşe Aktaş
dc.contributor.authorTekin, Askın
dc.contributor.authorArslan, Tayfun
dc.contributor.authorKantekin, Halit
dc.date.accessioned2024-11-21T10:46:42Z
dc.date.available2024-11-21T10:46:42Z
dc.date.issued2024
dc.departmentAÇÜ, Artvin Meslek Yüksekokulu, Laboratuvar Teknolojisi Bölümüen_US
dc.description.abstractIn this work, a series of aldehyde-substituted phthalocyanine compounds (1, 3, and 5) were prepared by the cyclotetramerization of the 4-(5-(diethylamino)-2-formylphenoxy) phthalonitrile (a) and the corresponding metal salts. Schiff base-substituted phthalocyanines (2, 4, and 6) were derived from an aldehyde-substituted phthalocyanine (1, 3, and 5) via the reaction of aldehyde-substituted phthalocyanines with an amine reagent. The compounds that were obtained were characterized using FT-IR, 1H {13C} NMR, UV–Vis, and MS spectra (a and 1–6). The inhibitory qualities of synthesized aldehyde and Schiff base-substituted complexes against the enzymes butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) were assessed. The majority of phthalocyanines exhibited strong enzyme-inhibiting properties. Out of the six produced phthalocyanines, 3 and 4 displayed the most intriguing profiles as submicromolar selective AChE inhibitors (IC50 = 0.060 ?M), whereas 1 demonstrated the most potent BChE inhibitor (IC50 = 0.024 ?M). The aggregation studies of CoPcs, CuPcs, and ZnPcs (1–6) were also carried out in this work.
dc.identifier.doi10.1002/aoc.7440
dc.identifier.endpage12en_US
dc.identifier.issn0268-2605
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1002/aoc.7440
dc.identifier.urihttps://hdl.handle.net/11494/4990
dc.identifier.volume38en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Ltden_US
dc.relation.ispartofApplied Organometallic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectAldehydeen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectPhthalocyanineen_US
dc.subjectSchiff Baseen_US
dc.subjectSynthesisen_US
dc.titleSynthesis and in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes activity of aldehyde and schiff base substituted cobalt (II), copper (II), and zinc (II) phthalocyaninesen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
ayse.aktaskamiloglu.pdf
Boyut:
1.4 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Artvin MYO Koleksiyonu Yayın Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu