Effects of transcutaneous auricular vagus nerve stimulation in individuals with primary dysmenorrhea: A randomized controlled trial

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dc.contributor.authorYıldız Kızkın, Zeynep
dc.contributor.authorYıldız, Rıdvan
dc.contributor.authorÖzden, Ali Veysel
dc.date.accessioned2026-07-16T08:25:35Z
dc.date.available2026-07-16T08:25:35Z
dc.date.issued2025
dc.departmentAÇÜ, Sağlık Hizmetleri Meslek Yüksekokulu, İş ve Uğraşı Terapisi Bölümü
dc.description.abstractBackground and aims: Transcutaneous auricular vagus nerve stimulation (taVNS) is a promising neuromodulation therapy with proved efficacy in treating various conditions, such as migraine, depression, abdominal pain, constipation, stroke, and sleep disorders. However, no randomized controlled trials have evaluated the effects of taVNS in patients with primary dysmenorrhea (PwPD). This study aims to investigate the impact of taVNS on pain, functional and emotional symptoms, and physical performance in PwPD. Materials and methods: In this study, conducted over two menstrual cycles, 34 PwPD were randomly assigned (1:1) to the taVNS or Sham groups. The treatment protocol comprised taVNS or sham treatment for five consecutive days, starting five days before the expected second menstrual period. The Numerical Rating Scale (NRS), pressure pain threshold (PPT), the Menstrual Symptom Questionnaire (MSQ), the Functional and Emotional Measure of Dysmenorrhea (FEMD), the Hamilton Anxiety Scale (HAM-A), and the 6-Minute Walking Test (6MWT) were evaluated at the first and subsequent menstrual cycles. Results: The difference between the groups was significant, favoring the taVNS group in the NRS, PPT, MSQ, FEMD, HAM-A, and 6MWT (for all, p < 0.05). Time, treatment, and time × treatment interaction were found to have significant effects on all treatment parameters except 6MWT (for all, p < 0.05). Conclusion: PwPD may benefit from taVNS, given it has shown efficacy in alleviating pain and menstrual symptoms while improving physical performance. Clinical trial registration: The Clinicaltrials.gov registration number for the study is NCT06146569.
dc.identifier.doi10.1016/j.neurom.2025.09.306
dc.identifier.endpage587
dc.identifier.issue4
dc.identifier.pmid41108303
dc.identifier.startpage576
dc.identifier.urihttps://hdl.handle.net/11494/6342
dc.identifier.volume29
dc.indekslendigikaynakPubMed
dc.institutionauthorYıldız Kızkın, Zeynep
dc.language.isoen
dc.publisherELSEVIER
dc.relation.ispartofNeuromodulation: Technology at the Neural Interface
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDysmenorrhea
dc.subjectElectric stimulation
dc.subjectFunction
dc.subjectMenstrual cycle
dc.subjectPain
dc.titleEffects of transcutaneous auricular vagus nerve stimulation in individuals with primary dysmenorrhea: A randomized controlled trial
dc.typeArticle

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