Development of pyrimidine-substituted schiff base and their axially silicon phthalocyanines as inhibitors of acetylcholinesterase and butyrylcholinesterase for alzheimer's disease therapy

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dc.authorid0000-0002-7347-4018
dc.authorid0000-0002-1426-5857
dc.authorid0000-0002-0362-9387
dc.authorid0000-0003-2625-2815
dc.contributor.authorAktaş Kamiloğlu, Ayşe
dc.contributor.authorArslan, Tayfun
dc.contributor.authorTekin, Aşkın
dc.contributor.authorKantekin, Halit
dc.date.accessioned2025-06-20T10:29:30Z
dc.date.available2025-06-20T10:29:30Z
dc.date.issued2025
dc.departmentAÇÜ, Artvin Meslek Yüksekokulu, Laboratuvar Teknolojisi Bölümü
dc.description.abstractIn this study, axially substituted silicon (IV) phthalocyanine complexes containing pyrimidine-substituted Schiff bases were synthesized and characterized. The Schiff bases (Pyr-1 and Pyr-2) were synthesized through a condensation reaction between pyrimidine derivatives and appropriate aldehydes, followed by their coordination with silicon (IV) to form the corresponding phthalocyanine complexes (Pyr-1-SiPc and Pyr-2-SiPc). The synthesized Schiff bases (Pyr-1 and Pyr-2) and silicon (IV) phthalocyanine derivatives (Pyr-1-SiPc and Pyr-2-SiPc) were subsequently tested in vivo for their inhibitory effect on the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). A substantial number of these compounds exhibited pronounced inhibitory activity against both enzymes. Notably, among the phthalocyanines and their precursor compounds, the most intriguing were identified as submicromolar selective inhibitors of AChE and BChE, with IC50 values of 4.26 μM and 6.46 μM, respectively.
dc.identifier.doi10.1002/aoc.70113
dc.identifier.issn02682605
dc.identifier.issue4
dc.identifier.scopus2-s2.0-86000049792
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/11494/5560
dc.identifier.volume39
dc.identifier.wosWOS:001438402300001
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorAktaş Kamiloğlu, Ayşe
dc.institutionauthorid0000-0002-7347-4018
dc.language.isoen
dc.publisherJohn Wiley and Sons Ltd
dc.relation.ispartofApplied Organometallic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAcetylcholinesterase
dc.subjectButyrylcholinesterase
dc.subjectPyrimidine
dc.subjectSchiff base
dc.subjectSilicon Phthalocyanine
dc.titleDevelopment of pyrimidine-substituted schiff base and their axially silicon phthalocyanines as inhibitors of acetylcholinesterase and butyrylcholinesterase for alzheimer's disease therapy
dc.typeArticle

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