Microwave-Assisted Synthesis of 5-Substituted 3-Amino-1,2,4-triazoles from Aminoguanidine Bicarbonate and Carboxylic Acids

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dc.authorid0000-0001-6373-5221en_US
dc.authorid0000-0001-8089-4646en_US
dc.authorid0000-0002-2819-3612en_US
dc.contributor.authorGümüş, Mustafa Kemal
dc.contributor.authorGorobets, Mykola Yu.
dc.contributor.authorUludağ, Nesimi
dc.date.accessioned2024-12-06T11:12:18Z
dc.date.available2024-12-06T11:12:18Z
dc.date.issued2024
dc.departmentAÇÜ, Artvin Meslek Yüksekokulu, Laboratuvar Teknolojisi Bölümüen_US
dc.description.abstractThe effect of the molar ratio between reagents, reaction time and temperature on the yield of 5-substituted 3-amino-1,2,4-triazoles obtained by the direct condensation of carboxylic acids with aminoguanidine bicarbonate under acid catalysis conditions was studied. As a result, a general green straightforward synthesis of the title compounds bearing aliphatic substituents or a phenyl ring was developed using sealed reaction vials under controlled microwave synthesis conditions that are suitable for the application of volatile starting carboxylic acids. Our straightforward synthetic method proposed in this work increases the synthetic accessibility of these widely used building blocks and therefore is able to significantly expand the structural diversity of compounds containing a triazole moiety for the needs of drug discovery.
dc.identifier.doi10.3390/pr12030573
dc.identifier.issn2227-9717
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2
dc.identifier.urihttp://dx.doi.org/10.3390/pr12030573
dc.identifier.urihttps://hdl.handle.net/11494/5130
dc.identifier.volume12en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en_US
dc.relation.ispartofProcesses
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject3-Amino-1,2,4-Triazolesen_US
dc.subjectAminoguanidineen_US
dc.subjectCarboxylic Acidsen_US
dc.subjectMicrowave-Assisted Synthesisen_US
dc.titleMicrowave-Assisted Synthesis of 5-Substituted 3-Amino-1,2,4-triazoles from Aminoguanidine Bicarbonate and Carboxylic Acidsen_US
dc.typeArticle

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