OXA- and GES-type beta-lactamases predominate in extensively drug-resistant Acinetobacter baumannii isolates from a Turkish University Hospital

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dc.authorid0000-0002-7757-6812en_US
dc.contributor.authorÇiçek, Ayşegül Çopur
dc.contributor.authorSaral, Ayşegül
dc.contributor.authorIraz, Meryem
dc.contributor.authorCeylan, Ayşenur
dc.contributor.authorDüzgün, Azer Özad
dc.contributor.authorPeleg, Anton Y.
dc.contributor.authorSandallı, Cemal
dc.date.accessioned2021-10-27T15:04:43Z
dc.date.available2021-10-27T15:04:43Z
dc.date.issued2014
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.descriptionThis study was supported by grants from Recep Tayyip Erdogan University (BAP-2012.106.01.11 and BAP-2011.102.03.3). AYP was supported by the Australian National Health and Medical Research Council (APP1047916 and APP1010114).en_US
dc.description.abstractWe determined the antibiotic susceptibility and genetic mechanisms of resistance in clinical strains of Acinetobacter baumannii from Istanbul, Turkey. A total of 101 clinical strains were collected between November 2011 and July 2012. Antimicrobial susceptibility was performed using the Vitek 2 Compact system and E-test. Multiplex PCR was used for detecting bla(OXA-51-like), bla(OXA-23-like), bla(OXA-40-like) and bla(OXA-58-like) genes. ISAba1, bla(IMP-like), bla(VIM-like), bla(GES), bla(VEB), bla(PER-2), aac-3-Ia and aac-6'-Ib and NDM-1 genes were detected by PCR and sequencing. By multiplex PCR, all strains were positive for bla(OXA-51), 79 strains carried bla(OXA-23) and one strain carried bla(OXA-40). bla(OXA-51) and bla(OXA-23) were found together in 79 strains. ISAba1 element was detected in 81 strains, and in all cases it was found upstream of bla(OXA-51). GES-type carbapenemases were found in 24 strains (GES-11 in 16 strains and GES-22 in 8 strains) while bla(PER-2), bla(VEB-1), bla(NDM-1), bla(IMP)- and bla(VIM)-type carbapenemases were not observed. Aminoglycoside modifying enzyme (aac-3-Ia and aac-6'Ib) genes were detected in 13 and 15 strains, respectively. Ninety-seven (96%) A. baumannii strains were defined as MDR and of these, 98% were extensively drug resistant (sensitive only to colistin). Colistin remains the only active compound against all clinical strains. As seen in other regions, OXA-type carbapenemases, with or without an upstream ISAba1, predominate but GES-type carbapenemases also appear to have a significant presence. REP-PCR analysis was performed for molecular typing and all strains were collected into 12 different groups. To our knowledge, this is the first report of GES-11 and OXA-40 in A. baumannii from Turkey.
dc.identifier.citationÇiçek, A. C., Saral, A., Iraz, M., Ceylan, A., Düzgün, A. O., Peleg, A. Y., & Sandallı, C. (2014). OXA-and GES-type β-lactamases predominate in extensively drug-resistant Acinetobacter baumannii isolates from a Turkish University Hospital. Clinical Microbiology and Infection, 20(5), 410-415.en_US
dc.identifier.doi10.1111/1469-0691.12338
dc.identifier.endpage415en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage410en_US
dc.identifier.urihttps://hdl.handle.net/11494/3552
dc.identifier.volume20en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSaral, Ayşegül
dc.language.isoenen_US
dc.publisherElsevier SCI LTDen_US
dc.relation.ispartofClinical Microbiology and Infection
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcinetobacter baumaen_US
dc.subjectnniiantimicrobial agentsen_US
dc.subjectGES-11en_US
dc.subjectGES-22en_US
dc.subjectOXA-40en_US
dc.titleOXA- and GES-type beta-lactamases predominate in extensively drug-resistant Acinetobacter baumannii isolates from a Turkish University Hospitalen_US
dc.typeArticle

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