In vitro and in silico evaluation of some plant extracts and phytocompounds against multidrug-resistant Gram-negative bacteria

Basit Öğe Kaydı
dc.authorid0000-0003-1721-0314en_US
dc.authorid0000-0002-7757-6812en_US
dc.contributor.authorAydemir, Eda
dc.contributor.authorSarıyer, Emrah
dc.contributor.authorAkyıldız, Esma
dc.contributor.authorÖzad Düzgün, Azer
dc.contributor.authorCamadan, Yasemin
dc.contributor.authorSaral Sarıyer, Ayşegül
dc.date.accessioned2021-08-16T07:43:08Z
dc.date.available2021-08-16T07:43:08Z
dc.date.issued2021
dc.departmentAÇÜ, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümüen_US
dc.description.abstractThe spread of multidrug-resistant Gram-negative (MDR) bacteria is a global public health problem, as infections caused by MDR Gram-negative bacteria are difcult to treat. New antibiotic agents need to be developed to overcome this problem, and phytochemicals show promise at this point. In this study, methanol extracts were prepared from cinnamon, thyme, nettle, white tea, rosehip, and antibacterial activity of the methanol extracts was studied against two MDR Gram-Negative bacteria (K. pneumoniae and A. baumannii) by broth microdilution method. The MICs of methanol extracts of cinnamon, rosehip, thyme, white tea for A. baumannii were found as 0.015125 g/ml, 0.07825 g/ml, 0.030625 g/ml, 0.00796875 g/ml, respectively. It was found that only cinnamon methanol extract had antibacterial activity in the used extract concentrations against K. pneumoniae and the MIC value was 0.0605 g/ml. The efects of plant methanol extract with antibacterial activity and imipenem combinations were studied in vitro using the checkerboard method. The FIC Indexes were obtained from the checkerboard results and it was observed that the combination of methanol extract and imipenem showed an antagonistic or additive/indiferent efect but not a synergistic efect. We evaluated the binding afnity of epigallocatechin 3-gallate, quercetin, cinnamaldehyde, carvacrol, and thymol phytocompounds using in silico methods, which are well known as a phytocompounds in white tea, cinnamon, thyme, nettle, and rosehip and have antibacterial activities. The results suggested that these phytocompounds should be supported with in vivo and in vitro experiments to investigate their potential for being inhibitor candidates.
dc.identifier.citationAydemir, E., Sarıyer, E., Akyıldız, E., Özad Düzgün, A., Camadan, Y., & Saral Sarıyer, A. (2021). In vitro and in silico evaluation of some plant extracts and phytocompounds against multidrug-resistant Gram-negative bacteria. Advances in Traditional Medicine, 1-11.en_US
dc.identifier.doi10.1007/s13596-021-00602-6
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/11494/3348
dc.identifier.volumeArticle in presen_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAydemir, Eda
dc.institutionauthorSarıyer, Emrah
dc.institutionauthorCamadan, Yasemin
dc.institutionauthorSaral Sarıyer, Ayşegül
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAdvances in Traditional Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultidrug-resistant Gram-negative bacteriaen_US
dc.subjectPlant methanol extractsen_US
dc.subjectOXA-23en_US
dc.subjectAntibacterial activityen_US
dc.subjectMolecular dockingen_US
dc.titleIn vitro and in silico evaluation of some plant extracts and phytocompounds against multidrug-resistant Gram-negative bacteriaen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
eda_aydemir.pdf
Boyut:
3.39 MB
Biçim:
Adobe Portable Document Format
Açıklama:
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Sağlık Hizmetleri Meslek Yüksekokulu Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu