Lactobacillus helveticus and Lactobacillus plantarum modulate renal antioxidant status in a rat model of fructose-induced metabolic syndrome

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dc.authorid0000-0003-0090-7369en_US
dc.contributor.authorKorkmaz, Ömer Adil
dc.contributor.authorSadi, Gökhan
dc.contributor.authorKocabaş, Aytaç
dc.contributor.authorYıldırım, Onur Gökhan
dc.contributor.authorSumlu, Esra
dc.contributor.authorKoca, Halit Buğra
dc.contributor.authorNalbantoğlu, Barbaros
dc.contributor.authorPektaş, Mehmet Bilgehan
dc.contributor.authorAkar, Fatma
dc.date.accessioned2021-02-24T09:31:55Z
dc.date.available2021-02-24T09:31:55Z
dc.date.issued2019
dc.departmentAÇÜ, Sağlık Hizmetlerien_US
dc.descriptionThis study was supported by grants from the Karamanoglu Mehmetbey University Research Fund (29-M-15) and Yildiz Technical University Research Fund (FDK-2018-3392).en_US
dc.description.abstractHigh dietary fructose intake causes a metabolic disorder and augments the risk of chronic kidney disease most likely due to oxidative stress. Probiotics could have antioxidant, antiinflammatory and immunoregulatory properties. The present study examined the influence of Lactobacillus helveticus and Lactobacillus plantarum supplementation on dietary fructose-induced metabolic changes and renal antioxidant/oxidant status of rats. Male Wistar rats were divided into four groups as follows: control; fructose; fructose plus L. helveticus; fructose plus L. plantarum. Fructose was given to the rats as a 20% solution in drinking water for 15 weeks. The probiotic supplementation was applied by gastric gavage once a day for six weeks. Several metabolic parameters in the plasma, gene and protein expressions of the main antioxidant enzymes in renal tissues of rats were measured. Dietary fructose-induced elevations in plasma insulin, triglyceride, VLDL, creatinine as well as renal urea levels were alleviated after treatment with L. helveticus and L. plantarum. Moreover, L. helveticus and L. plantarum supplementation recovered the changes in renal protein expression level of SOD1, SOD2 and CAT. In conclusion, supplementation with L. helveticus and L. plantarum has an improving effect on specific metabolic parameters and renal antioxidative enzymes in a fructose-induced metabolic disorder.
dc.identifier.citationKorkmaz,Ö. A., Sadi, G., Kocabaş, A, Yıldırım, O. G., Sumlu, E., Koca, H. B., Nalbantoğlu B., Pektaş, M. B., Akar, F. (2019). Lactobacillus helveticus and Lactobacillus plantarum modulate renal antioxidant status in a rat model of fructose-induced metabolic syndrome. Archives of Biological Sciences, 71(2), 265-273.en_US
dc.identifier.doi10.2298/ABS190123008K
dc.identifier.endpage273en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage265en_US
dc.identifier.urihttps://hdl.handle.net/11494/2644
dc.identifier.volume71en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYıldırım, Onur Gökhan
dc.language.isoenen_US
dc.publisherInst Bioloska Istrazivanja Sinisa Stankovicen_US
dc.relation.ispartofArchives of Biological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectDietary fructoseen_US
dc.subjectRenal antioxidant statusen_US
dc.subjectAntioxidant enzymesen_US
dc.subjectLactobacillus helveticusen_US
dc.subjectLactobacillus plantarum.en_US
dc.titleLactobacillus helveticus and Lactobacillus plantarum modulate renal antioxidant status in a rat model of fructose-induced metabolic syndromeen_US
dc.typeArticle

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