Preventing organ injury with carvacrol after renal ischemia/reperfusion

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dc.contributor.authorUyanoğlu, Mustafa
dc.contributor.authorCanbek, Mediha
dc.contributor.authorCeyhan, Emre
dc.contributor.authorŞentürk, Hakan
dc.contributor.authorBayramoğlu, Gökhan
dc.contributor.authorGündüz, Özlem
dc.contributor.authorÖzen, Ahmet
dc.contributor.authorTurgak, Özge
dc.date.accessioned2025-06-12T11:10:03Z
dc.date.available2025-06-12T11:10:03Z
dc.date.issued2011
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesi, İş Sağlığı ve Güvenliği Bölümü
dc.description.abstractIn this study, antioxidant enzyme activities and the histopathologic structure of rats were examined in order to determine the injury that occurs in the liver after renal I/R. There were 5 groups: Group I (Control), Group II (Right nephrectomy + untreated control), Group III (Right nephrectomy + I/R and olive oil treated), Group IV (Right nephrectomy + I/R and 25 mg.kg -1 carvacrol + olive oil treated group), Group V (Right nephrectomy + I/R and 50 mg.kg -1 carvacrol + olive oil treated group). 45 min of Ischemia and 24 h of Reperfusion were applied to all groups of rats except Group I. Liver CAT, SOD, Gpx enzyme activity and AST, ALT levels were evaluated at the end of the experiment and values close to the control group were obtained for rats to which 50 mg.kg -1 of carvacrol was administered. Significant injuries such as cellular degenerative changes, sinusoidal congestion and cytoplasmic vacuolation were determined for Group II in light microscopic examinations of liver sections. 25 mg.kg -1 of carvacrol dose was found to be protective in Group IV.
dc.identifier.endpage80
dc.identifier.issn19960875
dc.identifier.issue1
dc.identifier.scopus2-s2.0-79551714951
dc.identifier.startpage72
dc.identifier.urihttps://hdl.handle.net/11494/5484
dc.identifier.volume5
dc.identifier.wosWOS:000287938800010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorBayramoğlu, Gökhan
dc.language.isoen
dc.relation.ispartofJournal of Medicinal Plants Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntioxidant
dc.subjectCarvacrol
dc.subjectLiver
dc.subjectOxidative stress
dc.subjectRemote organ
dc.subjectRenal ischemia/reperfusion
dc.titlePreventing organ injury with carvacrol after renal ischemia/reperfusion
dc.typeArticle

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