Investigation of class 1 integrons with antibiotic resistance genes in multidrug-resistant acinetobacter baumannii strains and determination of plant extract effects on multidrug-resistant isolates

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dc.authorid0000-0002-7757-6812en_US
dc.contributor.authorSaral, Ayşegül
dc.contributor.authorCinemre, Sedanur
dc.contributor.authorOkumuş, Funda
dc.contributor.authorAkar, Zeynep
dc.contributor.authorÇiçek, Ayşegül Çopur
dc.contributor.authorDüzgün, Azer Özad
dc.date.accessioned2021-12-01T17:50:31Z
dc.date.available2021-12-01T17:50:31Z
dc.date.issued2021
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractThis study aimed to investigate the presence of resistance genes in multidrug-resistant A. baumannii isolates as well as to determine the antibacterial activity of selected plant extracts against isolates. 41 strains were isolated from various clinical samples. PCR tests were performed using the primers. Methanol was used as solvent for the preparation of the plant extracts. MIC values of the plant extracts were determined by the broth microdilution method. The bla(OXA-)(23), bla(CTX-M-1), bla(CTX-M-2), bla(GES) genes and Class 1 integrons were detected in five isolated strains. The lowest MIC value (2.25 mg/mL) was determined for the Echinacea putpurea extract, while the highest MIC value (50 mg/mL) was determined for the Morus alba extract. Determination of the antibacterial effect of plants extracts used in the study against A. baumannii isolates shows the importance of screening the antibacterial activity of plants in the fight against antibiotic resistance.
dc.description.abstractStudiul a avut ca scop investigarea genelor de rezisten?? ale izolatelor de A. baumannii multirezistente, precum ?i determinarea activit??ii antibacteriene a unor extracte vegetale supra a 41 specii microbiene izolate din diferite probe clinice. Metanolul a fost folosit ca solvent de extrac?ie. Valorile concentra?iei minime inhibitorii ale extractelor ob?inute au fost determinate prin metoda microdilu?iei. Genele blaOXA-23, blaCTX-M-1 , blaCTX-M2 ?i blaGES, al?turi de integroni din clasa 1 au fost decelate pentru 5 specii izolate. Valoarea MIC cea mai sc?zut? (2,25 mg/mL) a fost ob?inut? pentru extractul din Echinaceea purpurea, în timp ce cea mai mare valoare MIC (50 mg/mL) a fost determinat? pentru extractul de Morus alba. Determinarea efectului antibacterian ale extractelor vegetale împotriva izolatelor de A. baumannii arat? importan?a screeningului activit??ii antibacteriene a plantelor în lupta împotriva rezisten?ei la antibiotice.
dc.identifier.citationSaral, A., Cinemre, S., Okumuş, F., Akar, Z., Çopur Çiçek, A., & Düzgün, A. (2021). Investigation of class 1 integrons with antibiotic resistance genes in multidrug-resistant acinetobacter baumannii strains and determination of plant extract effects on multidrug-resistant isolates, Farmacia, 69(5), 914-918.en_US
dc.identifier.doi10.31925/farmacia.2021.5.13
dc.identifier.endpage918en_US
dc.identifier.issn0014-8237
dc.identifier.issn2065-0019
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage914en_US
dc.identifier.urihttps://hdl.handle.net/11494/3575
dc.identifier.volume69en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSaral, Ayşegül
dc.language.isoenen_US
dc.publisherSoc Stiinte Farmaceutice Romaniaen_US
dc.relation.ispartofFarmacia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMICen_US
dc.subjectPlant extracten_US
dc.subjectResistanceen_US
dc.titleInvestigation of class 1 integrons with antibiotic resistance genes in multidrug-resistant acinetobacter baumannii strains and determination of plant extract effects on multidrug-resistant isolatesen_US
dc.typeArticle

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