Six Algerian plants: phenolic profile, antioxidant, antimicrobial activities associated with different simulated gastrointestinal digestion phases and antiproliferative properties

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dc.authorid0000-0003-2561-807Xen_US
dc.contributor.authorEr Kemal, Mehtap
dc.contributor.authorBakchiche, Boulanouar
dc.contributor.authorKemal, Mehmet
dc.contributor.authorCheraif, Kadour
dc.contributor.authorKara, Yakup
dc.contributor.authorBardaweel, Sanaa K.
dc.date.accessioned2023-02-20T08:00:30Z
dc.date.available2023-02-20T08:00:30Z
dc.date.issued2023
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractMediterranean countries, including Algeria, have medicinal plants used in folk medicine, such as Artemisia campestris L., Artemisia herba-alba Asso, Juniperus phoenicea L., Juniperus oxycedrus L., Mentha pulegium L., and Lavandula angustifolia Mill. It is noteworthy that the bioaccessibility of their polyphenolic ingredients have not been critically evaluated before. Methods: The bioactive properties of the aqueous extracts of Artemisia campestris L., Artemisia herba-alba Asso, Juniperus phoenicea L., Juniperus oxycedrus L., Mentha pulegium L., and Lavandula angustifolia Mill. were investi- gated. They were subjected to a simulated gastrointestinal digestion to evaluate the antioxidant, antimicrobial activities and total polyphenol contents. Their antiproliferative activities against three human cancer cell lines (MCF-7, T47D, and Caco-2) were also performed using the aqueous extracts. The phenolic profile was also studied by reversed-phase high-performance liquid chromatography coupled to ultraviolet spectrometry detector (RP-HPLC-UV). Results: The results indicated that bioaccessibility of total phenolic compounds after the post-gastric, intestinal, and colon phases was in the ranges of 4.34–11.57 %, 0–0.55 %, and 3.92–9.24 %, respectively when compared with their aqueous extracts. Intestinal and colon phase samples collected from intestinal digestion of six plant extracts did not have any antioxidant activity. Juniperus spp. extracts had the highest antiproliferative activity compared to the results obtained from other tested species. Conclusions: The high antioxidant and cytotoxic activities of Juniperus samples may be attributed to the higher levels of total phenols, as well as the catechins, rutin and caffeic acid, whilst M. pulegium extract with the lowest phenolic content and lower amounts of these metabolites, having p-coumaric acid as a predominant phenolic compound, was shown to be less effective as an antioxidant and anticancer agent.
dc.identifier.citationEr Kemal, M., Bakchiche, B., Kemal, M., Cheraif, K., Kara, Y., Bardaweel, S. K., Miguel, M. G., Yildiz, O., & Ghareeb, M. A. (2023). Six Algerian plants: Phenolic profile, antioxidant, antimicrobial activities associated with different simulated gastrointestinal digestion phases and antiproliferative properties. Journal of Herbal Medicine, 38, 100636.en_US
dc.identifier.doi10.1016/j.hermed.2023.100636
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.hermed.2023.100636
dc.identifier.urihttps://hdl.handle.net/11494/4710
dc.identifier.volume38en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKemal, Mehmet
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofJournal of Herbal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlgerian plantsen_US
dc.subjectBioaccessibilityen_US
dc.subjectBioactivityen_US
dc.subjectIn vitro digestionen_US
dc.subjectArtemisiaen_US
dc.subjectJuniperusen_US
dc.subjectMenthaen_US
dc.subjectLavandulaen_US
dc.titleSix Algerian plants: phenolic profile, antioxidant, antimicrobial activities associated with different simulated gastrointestinal digestion phases and antiproliferative propertiesen_US
dc.typeArticle

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