The examination of protective effects of gallic acid against damage of oxidative stress during induced-experimental renal ischemia-reperfusion in experiment

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dc.authorid0000-0003-2779-6478en_US
dc.contributor.authorCanbek, Mediha
dc.contributor.authorBayramoğlu, Gökhan
dc.contributor.authorŞentürk, Hakan
dc.contributor.authorVatan, Öztopcu A. P.
dc.contributor.authorUyanoğlu, Mustafa
dc.contributor.authorCeyhan, Emel Mashaki
dc.contributor.authorÖzen, Ahmet
dc.contributor.authorDurmuş, Başak
dc.contributor.authorKartkaya, Kazım
dc.contributor.authorKanbak, Güngör
dc.date.accessioned2021-10-26T08:17:02Z
dc.date.available2021-10-26T08:17:02Z
dc.date.issued2014
dc.departmentAÇÜ, Artvin Meslek Yüksekokulu, Laboratuvar Teknolojisi Bölümüen_US
dc.description.abstractAim: In this study, probable effects of gallic acid were investigated in experimentally induced renal I/R injury in rats. Material and methods: For this purpose, each group consisted of 7 Sprague dawley male albino rats. Groups were defined as follows; Group I: control group; Group II: I/R group; Group III, IV and V: I/R+Gallic acid (50, 100 and 200 mg.kg(-1) respectively-i.p.). Left kidney was removed by nephrectomy except for Group I. I/R was induced in the other kidney. Gallic acid was given 15 mins before ischemia induction. SOD, CAT and Gpx activities were determined by electrophoresis. MDA, MPO levels were determined spectrophotometrically. Histopathological investigations were also performed in kidney tissues. BUN and Creatinine levels in serum were determined. Results: BUN, Creatinine and MDA levels were statistically significant but MPO level was not statistically significantly increased in Group II. For SOD, CAT, Gpx activities in Group II, an increase was determined with respect to Group I. Histopathological investigations revealed widespread hyperemia in glomerulus, expansion of the structure between tubules and cell disruptions in Group II. In Group V (200 mg.kg-1 gallic acid), in terms of biochemical parameters, in spite of the significant decrease in BUN, Creatinine and MDA levels; a decrease was determined in SOD, CAT and Gpx isoenzyme activities. Group V showed histologically that I/R injury had been prevented to a greater extent and appearances were close to the control. Conclusion: As a result, in terms of our study, evaluations regarding kidney functions and histopathology have shown that gallic acid has protective effects in renal I/R injury (Tab. 2, Fig. 5, Ref. 36). Text in PDF www.elis.sk.
dc.identifier.citationCanbek, M., Bayramoglu, G., Senturk, H., AP, O. V., Uyanoglu, M., Ceyhan, E., ... & Kanbak, G. (2014). The examination of protective effects of gallic acid against damage of oxidative stress during induced-experimental renal ischemia-reperfusion in experiment. Bratislavske lekarske listy, 115(9), 557-562.en_US
dc.identifier.doi10.4149/BLL_2014_108
dc.identifier.endpage562en_US
dc.identifier.issn0006-9248
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage557en_US
dc.identifier.urihttps://hdl.handle.net/11494/3546
dc.identifier.volume115en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBayramoğlu, Gökhan
dc.language.isoenen_US
dc.publisherComenius Universityen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKidneyen_US
dc.subjectGallic aciden_US
dc.subjectIschemia-reperfusien_US
dc.subjectOnoxidative stressen_US
dc.titleThe examination of protective effects of gallic acid against damage of oxidative stress during induced-experimental renal ischemia-reperfusion in experimenten_US
dc.typeArticle

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