Investigation of the possible protective role of gallic acid on paraoxanase and arylesterase activities in livers of rats with acute alcohol intoxication

Basit Öğe Kaydı
dc.authorid0000-0003-2779-6478en_US
dc.contributor.authorKartalkaya, Kazım
dc.contributor.authorOğlakçı, Ayşegül
dc.contributor.authorŞentürk, Hakan
dc.contributor.authorBayramoğlu, Gökhan
dc.contributor.authorCanbek, Mediha
dc.contributor.authorKanbak, Güngör
dc.date.accessioned2021-12-06T11:45:22Z
dc.date.available2021-12-06T11:45:22Z
dc.date.issued2013
dc.departmentAÇÜ, Artvin Meslek Yüksekokulu, Laboratuvar Teknolojisi Bölümüen_US
dc.description.abstractGallic acid, a polyphenyl class natural product from gallnut and green tea, is known to be antioxidant, anti-inflammatory and radical scavenger. In this study, we aimed to investigate the possible protective effects of gallic acid on paraoxonase and arylesterase activities in liver exposed to acute alcohol intoxication. Paraoxonase and arylesterase activities in liver tissue and serum aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase levels were measured. Histological investigations were also made. In our study, we observed a significant increase of serum alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase activities, which are indicators of liver damage after acute ethanol consumption. Gallic acid therapy has significantly reduced the increase in these biomarkers, indicating a possible hepatoprotective effect of gallic acid. Ethanol consumption caused a significant decrease in liver paraoxonase activity (P<0.001). Gallic acid treatment partly restored this decreased paraoxonase activity, which resulted from ethanol administration. A gallic acid dose of 100mg/kg was observed as highest restoring effect for paraoxonase activity (P<0.05). The activity of arylesterase was decreased in the ethanol group as compared with the control group, but this was not significant. However, 50mg/kg of gallic acid treatment restored the loss of this activity due to ethanol exposure (P<0.001). We observed that gallic acid ameliorates the liver damage caused by excessive alcohol consumption in a dose-dependent way. Our results in this study showed that gallic acid might have a protective effect against alcoholic liver disease.
dc.identifier.citationKartkaya, K., Oğlakçı, A., Şentürk, H., Bayramoğlu, G., Canbek, M., & Kanbak, G. (2013). Investigation of the possible protective role of gallic acid on paraoxanase and arylesterase activities in livers of rats with acute alcohol intoxication. Cell biochemistry and function, 31(3), 208-213.en_US
dc.identifier.doi10.1002/cbf.2874
dc.identifier.endpage213en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage208en_US
dc.identifier.urihttps://hdl.handle.net/11494/3586
dc.identifier.volume31en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBayramoğlu, Gökhan
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biochemistry and Function
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGallic aciden_US
dc.subjectAlcoholen_US
dc.subjectLiveren_US
dc.subjectParaoxonaseen_US
dc.subjectArylesteraseen_US
dc.titleInvestigation of the possible protective role of gallic acid on paraoxanase and arylesterase activities in livers of rats with acute alcohol intoxicationen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
kazim_kartkaya.pdf
Boyut:
724.23 KB
Biçim:
Adobe Portable Document Format
Açıklama:
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Artvin MYO Koleksiyonu Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu