Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols and their derivatives including natural products: Vidalol B

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dc.authorid0000-0001-5968-7511en_US
dc.contributor.authorBalaydın, Halis Türker
dc.contributor.authorŞentürk, Murat
dc.contributor.authorGöksoy, Süleyman
dc.contributor.authorMenzek, Abdullah
dc.date.accessioned2022-01-19T06:43:21Z
dc.date.available2022-01-19T06:43:21Z
dc.date.issued2012
dc.departmentAÇÜ, Eğitim Fakültesi, Temel Eğitim Bölümüen_US
dc.description.abstractA series of bisphenol, bromophenol, and methoxyphenol derivatives (2–24) including the natural bromophenols vidalol B, 3,4,6-tribromo-5-(2,5-dibromo-3,4-dihydroxybenzyl)benzene-1,2-diol (2) and 5,5?-methylenebis(3,4,6-tribromo-benzene-1,2-diol) (3) were prepared. In the current study, inhibition of four human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes, I, II, IV, and VI, with these compounds 2–24 was investigated. The compounds 2–24 were found to be promising carbonic anhydrase inhibitors, some of which showed interesting inhibitory activities. Some of the compounds investigated here showed effective hCA inhibitory activity, and might be used as leads for generating novel carbonic anhydrase inhibitors which are valuable drug candidates for the treatment of glaucoma, epilepsy, gastric and duodenal ulcers, neurological disorders, and osteoporosis.
dc.identifier.citationBalaydın, H. T., Şentürk, M., Göksu, S., & Menzek, A. (2012). Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols and their derivatives including natural products: Vidalol B. European journal of medicinal chemistry, 54, 423-428.en_US
dc.identifier.doi10.1016/j.ejmech.2012.05.025
dc.identifier.endpage428en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage423en_US
dc.identifier.urihttps://hdl.handle.net/11494/3702
dc.identifier.volume54en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorŞentürk, Murat
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofEuropean Journal of Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitakTBAG-107T348
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhenolen_US
dc.subjectBrominationen_US
dc.subjectBromophenolsen_US
dc.subjectDiphenylmethaneen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectGlaucomaen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectVidalol Aen_US
dc.subjectVidalol Ben_US
dc.titleSynthesis and carbonic anhydrase inhibitory properties of novel bromophenols and their derivatives including natural products: Vidalol Ben_US
dc.typeArticle

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