Synthesis of some new hybride molecules containing several azole moieties and investigation of their biological activities
Yükleniyor...
Dosyalar
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Maik Nauka/Interperiodica/Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
1,2,4-Triazole-3-one prepared from tryptamine was converted to the corresponding carbothioamides by several steps. Their treatment with ethyl bromoacetate or 4-chlorophenacyl bromide produced the corresponding 5-oxo-1,3-thiazolidine or 3-(4-chlorophenyl)-1,3-thiazole derivatives. Acetohydrazide derivative that was obtained starting from tryptamine, was converted to the corresponding Schiff basis and sulfonamide by the treatment with suitable aldehydes and benzensulphonyl chloride, respectively. 2-[(4-Amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-3-yl)methyl]-4-[2-(1H-indole-3-yl)ethyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one was synthesized starting from hydrazide via the formation of the corresponding 1,3,4-oxadiazole compound, while the other bitriazole compounds were obtained by intramolecular cyclisation of carbothioamides in basic media. The treatment of 1,2,4-triazole or 1,3,4-oxadiazole compound with several amines generated the corresponding Mannich bases. Ethyl (2-amino-1,3-thiazole-4-yl)acetate was converted to the corresponding 1,3,4-oxadiazole derivative, arylidenehydrazides, 1,2,4-triazole-3-one and 5-oxo-1,3-oxazolidine derivatives by several steps. The structural assignments of new compounds were based on their elemental analysis and spectral (FT IR, H-1 NMR, C-13 NMR and LC-MS) data. The antimicrobial, antilipase and antiurease activity studies revealed that some of the synthesized compounds showed antimicrobial, antilipase and/or antiurease activity.
Açıklama
Anahtar Kelimeler
1,2,4-triazole, 1,3,4-oxadiazole, 1,3-thiazolidinone, 1,3,4-thiadiazole, Piperazine, Biological activity
Kaynak
Russian Journal Of Bioorganic Chemistry
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
40
Sayı
3
Künye
Ceylan, S., Bayrak, H., Demirbaş, A., Ülker, S., Alpay-Karaoğlu, S., & Demirbaş, N. (2014). Synthesis of some new hybride molecules containing several azole moieties and investigation of their biological activities. Russian Journal of Bioorganic Chemistry, 40(3), 314-329.
