Synthesis of some new hybride molecules containing several azole moieties and investigation of their biological activities

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dc.contributor.authorCeylan, Şule
dc.contributor.authorBayrak, Hacer
dc.contributor.authorDemirbaş, Ahmet
dc.contributor.authorÜlker, Serdar
dc.contributor.authorAlpay Karaoğlu, Şengül
dc.contributor.authorDemirbaş, Neslihan
dc.date.accessioned2021-10-25T13:47:06Z
dc.date.available2021-10-25T13:47:06Z
dc.date.issued2014
dc.departmentAÇÜ, Orman Fakültesi, Orman Endüstri Mühendisliği Bölümüen_US
dc.description.abstract1,2,4-Triazole-3-one prepared from tryptamine was converted to the corresponding carbothioamides by several steps. Their treatment with ethyl bromoacetate or 4-chlorophenacyl bromide produced the corresponding 5-oxo-1,3-thiazolidine or 3-(4-chlorophenyl)-1,3-thiazole derivatives. Acetohydrazide derivative that was obtained starting from tryptamine, was converted to the corresponding Schiff basis and sulfonamide by the treatment with suitable aldehydes and benzensulphonyl chloride, respectively. 2-[(4-Amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-3-yl)methyl]-4-[2-(1H-indole-3-yl)ethyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one was synthesized starting from hydrazide via the formation of the corresponding 1,3,4-oxadiazole compound, while the other bitriazole compounds were obtained by intramolecular cyclisation of carbothioamides in basic media. The treatment of 1,2,4-triazole or 1,3,4-oxadiazole compound with several amines generated the corresponding Mannich bases. Ethyl (2-amino-1,3-thiazole-4-yl)acetate was converted to the corresponding 1,3,4-oxadiazole derivative, arylidenehydrazides, 1,2,4-triazole-3-one and 5-oxo-1,3-oxazolidine derivatives by several steps. The structural assignments of new compounds were based on their elemental analysis and spectral (FT IR, H-1 NMR, C-13 NMR and LC-MS) data. The antimicrobial, antilipase and antiurease activity studies revealed that some of the synthesized compounds showed antimicrobial, antilipase and/or antiurease activity.
dc.identifier.citationCeylan, S., Bayrak, H., Demirbaş, A., Ülker, S., Alpay-Karaoğlu, S., & Demirbaş, N. (2014). Synthesis of some new hybride molecules containing several azole moieties and investigation of their biological activities. Russian Journal of Bioorganic Chemistry, 40(3), 314-329.en_US
dc.identifier.doi10.1134/S1068162014030145
dc.identifier.endpage329en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage314en_US
dc.identifier.urihttps://hdl.handle.net/11494/3542
dc.identifier.volume40en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorCeylan, Şule
dc.language.isoenen_US
dc.publisherMaik Nauka/Interperiodica/Springeren_US
dc.relation.ispartofRussian Journal Of Bioorganic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject1,2,4-triazoleen_US
dc.subject1,3,4-oxadiazoleen_US
dc.subject1,3-thiazolidinoneen_US
dc.subject1,3,4-thiadiazoleen_US
dc.subjectPiperazineen_US
dc.subjectBiological activityen_US
dc.titleSynthesis of some new hybride molecules containing several azole moieties and investigation of their biological activitiesen_US
dc.typeArticle

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