Synthesis and biological evaluation of new Mannich and Schiff bases containing 1,2,4-triazole and 1,3,4-oxadiazole nucleus
Yükleniyor...
Dosyalar
Tarih
2016
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
5-(Pyridine-3-yl)-1, 3, 4-oxadiazole-2-thiole 2, obtaining starting from nicotinic acid hydrazide were converted to the corresponding Mannich bases (3a–c) by the reaction with several heterocyclic amines in the presence of formaldehyde. 1,2,4-Triazole-3-thiole, (4) prepared from 1,3,4-oxadiazole-2-thiole (2) was converted to the corresponding Mannich bases (5a–e) by several steps. The synthesis of Schiff bases (6a–d) was performed from the reaction of the corresponding triazol-3-thioles with various aromatic aldehydes. The treatment of Schiff bases containing 1,2,4-triazoles 6c and 6d with morpholine or thiomorpholine generated the corresponding Mannich bases 7a, b and 8a, b. The synthesized compounds were screened for their antimicrobial, antilipase, and antiurease activities. Some of them were found to possess good-moderate antimicrobial, antiurease, and/or antilipase activity.
Açıklama
Anahtar Kelimeler
s 1, 2, 4-Triazole, 1, 3, 4-Oxadizole, Nicotonic acid hydrazide, Mannich base, Schiff base, Biological activity
Kaynak
Medicinal Chemistry Research
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
25
Sayı
9
Künye
Ceylan, Ş. (2016). Synthesis and biological evaluation of new Mannich and Schiff bases containing 1, 2, 4-triazole and 1, 3, 4-oxadiazole nucleus. Medicinal Chemistry Research, 25(9), 1958-1970.
