Synthesis and biological evaluation of new Mannich and Schiff bases containing 1,2,4-triazole and 1,3,4-oxadiazole nucleus
| dc.contributor.author | Ceylan, Şule | |
| dc.date.accessioned | 2021-07-07T07:38:14Z | |
| dc.date.available | 2021-07-07T07:38:14Z | |
| dc.date.issued | 2016 | |
| dc.department | AÇÜ, Orman Fakültesi, Orman Endüstri Mühendisliği Bölümü | en_US |
| dc.description.abstract | 5-(Pyridine-3-yl)-1, 3, 4-oxadiazole-2-thiole 2, obtaining starting from nicotinic acid hydrazide were converted to the corresponding Mannich bases (3a–c) by the reaction with several heterocyclic amines in the presence of formaldehyde. 1,2,4-Triazole-3-thiole, (4) prepared from 1,3,4-oxadiazole-2-thiole (2) was converted to the corresponding Mannich bases (5a–e) by several steps. The synthesis of Schiff bases (6a–d) was performed from the reaction of the corresponding triazol-3-thioles with various aromatic aldehydes. The treatment of Schiff bases containing 1,2,4-triazoles 6c and 6d with morpholine or thiomorpholine generated the corresponding Mannich bases 7a, b and 8a, b. The synthesized compounds were screened for their antimicrobial, antilipase, and antiurease activities. Some of them were found to possess good-moderate antimicrobial, antiurease, and/or antilipase activity. | |
| dc.identifier.citation | Ceylan, Ş. (2016). Synthesis and biological evaluation of new Mannich and Schiff bases containing 1, 2, 4-triazole and 1, 3, 4-oxadiazole nucleus. Medicinal Chemistry Research, 25(9), 1958-1970. | en_US |
| dc.identifier.doi | 10.1007/s00044-016-1640-9 | |
| dc.identifier.endpage | 1970 | en_US |
| dc.identifier.issue | 9 | en_US |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.startpage | 1958 | en_US |
| dc.identifier.uri | https://hdl.handle.net/11494/3274 | |
| dc.identifier.volume | 25 | en_US |
| dc.identifier.wosquality | N/A | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.institutionauthor | Ceylan, Şule | |
| dc.language.iso | en | en_US |
| dc.publisher | Springer | en_US |
| dc.relation.ispartof | Medicinal Chemistry Research | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | s 1, 2, 4-Triazole | en_US |
| dc.subject | 1, 3, 4-Oxadizole | en_US |
| dc.subject | Nicotonic acid hydrazide | en_US |
| dc.subject | Mannich base | en_US |
| dc.subject | Schiff base | en_US |
| dc.subject | Biological activity | en_US |
| dc.title | Synthesis and biological evaluation of new Mannich and Schiff bases containing 1,2,4-triazole and 1,3,4-oxadiazole nucleus | en_US |
| dc.type | Article |
