Preventive role of gallic acid on alcohol dependent and cysteine protease-mediated pancreas injury

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dc.authorid0000-0003-2779-6478en_US
dc.contributor.authorKanbak, Güngör
dc.contributor.authorCanbek, Mediha
dc.contributor.authorOğlakçı, Ayşegül
dc.contributor.authorKartkaya, Kazım
dc.contributor.authorŞentürk, Hakan
dc.contributor.authorBayramoğlu, Gökhan
dc.contributor.authorBal, Cengiz
dc.contributor.authorGöl, Burak
dc.contributor.authorÖzmen, Ayşe
dc.date.accessioned2022-01-21T12:43:39Z
dc.date.available2022-01-21T12:43:39Z
dc.date.issued2012
dc.departmentAÇÜ, Artvin Meslek Yüksekokulu, Laboratuvar Teknolojisi Bölümüen_US
dc.description.abstractIn order to investigate an association between alcohol consumption and lysosomal cysteine protease induced pancreatic injury and preventive effect of gallic acid as dose-dependent, we determined myeloperoxidase and malondialdehyde levels, serum amylase activities and cathepsin B and L activities in the cytosolic and lysosomal fractions of pancreatic tissue in the ethanol (8 g/kg) and ethanol plus gallic acid (at different doses 50, 100 and 200 mg/kg) given rats. Absolute ethanol (8 g/kg) was given by oral gavage. Gallic acid was dissolved in the saline (2 ml/kg) and administered before 30 min the oral administration of ethanol. Pancreatic myeloperoxidase and also malondialdehyde levels and serum amylase activities were measured. Besides, histological investigations were made. Cathepsin B activities in the cytosolic fraction were decreased by gallic acid (200 mg/kg) and increased in ethanol given rats. Cytosolic/lysosomal ratio of cathepsin B and L were found to be low in the all doses of gallic acid as compared to ethanol group. Serum amylase, pancreatic myeloperoxidase activities and malondialdehyde levels in the ethanol group were higher than in the control group. These were not statistically significant for myeloperoxidase and malondialdehyde. Also, our histopathologic results indicated that ethanol administration increased pancreatic tissue injury. Gallic acid especially at 200 mg/kg improved ethanol-mediated pancreatic tissue damage.In conclusion, gallic acid treatments were decreased release of lysosomal cathepsin B and L enzymes into cytoplasmic fraction and prevented alcohol mediated pancreatic tissue injury. Preventive effect of gallic acid might be dose-dependent.
dc.identifier.citationKanbak, G., Canbek, M., Oğlakçı, A., Kartkaya, K., Şentürk, H., Bayramoğlu, G., ... & Özmen, A. (2012). Preventive role of gallic acid on alcohol dependent and cysteine protease-mediated pancreas injury. Molecular biology reports, 39(12), 10249-10255.en_US
dc.identifier.doi10.1007/s11033-012-1901-8
dc.identifier.endpage10255en_US
dc.identifier.issue12en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage10249en_US
dc.identifier.urihttps://hdl.handle.net/11494/3709
dc.identifier.volume39en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBayramoğlu, Gökhan
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCathepsinen_US
dc.subjectEthanolen_US
dc.subjectGallic aciden_US
dc.subjectPancreasen_US
dc.titlePreventive role of gallic acid on alcohol dependent and cysteine protease-mediated pancreas injuryen_US
dc.typeArticle

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