Chitosan and blueberry treatment induces arginase activity and inhibits nitric oxide production during acetaminophen-induced hepatotoxicity

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dc.contributor.authorÖzçelik, Eda
dc.contributor.authorUslu, Sema
dc.contributor.authorBurukoğlu, Dilek
dc.contributor.authorMusmul, Ahmet
dc.date.accessioned2020-11-13T05:32:01Z
dc.date.available2020-11-13T05:32:01Z
dc.date.issued2014
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.description.abstractBackground: Liver diseases have become a major problem of the worldwide. More than 50% of all cases of liver failure can be attributed to drugs. Among these, acetaminophen is the most common cause. Objective: The aim of this study was to investigate the the hepatoprotective effects of blueberry and chitosan on tissue arginase activity, ornithine and nitric oxide levels during the acetaminophen-induced hepatotoxicity. Materials and Methods: Acetaminophen (250 mg/kg body weight per day), blueberry (60 mg/kg body weight per day) and, chitosan (200 mg/kg body weight per day) were administered to the rats by oral gavage during the experimental period. Results: Blueberry and chitosan significantly decreased liver arginase activity and ornithine levelsand and increased nitric oxide levels. Glutathione levels were remarkably increased by chitosan and blueberry treatments. Conclusion: The results of the present study indicate that blueberry and chitosan effectively protected against the acetaminophen-induced hepatotoxicity. The hepatoprotective effect afforded by blueberry and chitosan can be attributed to its antioxidant and anti-inflammatory activities.
dc.identifier.citationÖzçelik, E., Uslu, S., Burukoğlu, D., & Musmul, A. (2014). Chitosan and blueberry treatment induces arginase activity and inhibits nitric oxide production during acetaminophen-induced hepatotoxicity. Pharmacognosy Magazine, 10(38), 217-234.en_US
dc.identifier.doi10.4103/0973-1296.133234
dc.identifier.endpage234en_US
dc.identifier.issue38en_US
dc.identifier.startpage217en_US
dc.identifier.urihttps://hdl.handle.net/11494/2450
dc.identifier.volume10en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzçelik, Eda
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofPharmacognosy Magazine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcetaminophen hepatotoxicityen_US
dc.subjectArginaseen_US
dc.subjectBlueberryen_US
dc.subjectChitosanen_US
dc.subjectOrnithineen_US
dc.titleChitosan and blueberry treatment induces arginase activity and inhibits nitric oxide production during acetaminophen-induced hepatotoxicityen_US
dc.typeArticle

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