Octa- and tetra-substituted phthalocyanines with methoxyeugenol group: synthesis, characterization and in vitro antimicrobial activity

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dc.authorid0000-0002-7347-4018en_US
dc.contributor.authorKamiloğlu Aktaş , Ayşe
dc.contributor.authorDirekel, Şahin
dc.contributor.authorYalazan, Hadise
dc.contributor.authorKantekin, Halit
dc.contributor.authorAcar, İrfan
dc.date.accessioned2020-06-02T08:26:43Z
dc.date.available2020-06-02T08:26:43Z
dc.date.issued2020
dc.departmentAÇÜ, Artvin Meslek Yüksekokuluen_US
dc.description.abstractIn this study, the novel phthalonitrile derivatives1and2weresynthesized. Tetra-substituted metal-free1a(H2Pc) and metalloph-thalocyanines (ZnPc1b,CoPc1cand CuPc1d) bearing four per-ipheral 4-allyl-2,6-dimethoxyphenol (methoxy-eugenol) groupsand octa-substituted metal-free2aand metallophthalocyanines(ZnPc2b,CoPc2cand CuPc2d) bearing eight peripheralmethoxy-eugenol group were synthesized. All new synthesizedcompounds are characterized by IR,13Cf1HgNMR (for1and2),UV-Vis (for1a–2d) and mass spectroscopy. Antimicrobial activitiesof the synthesized phthalonitrile derivatives (1and2) andphthalocyanine compounds1a–2dwere determined by microdi-lution broth method against nine different bacteria and one yeastspecies. In this study, CoPc (2c) compound, which has eight per-ipheral 4-allyl-2,6-dimethoxyphenol, had the highest antibacterialactivity (minimum inhibitory concentration [MIC]¼312lg/mL). Inaddition,1b,1d,2band2dwere found to be effective on atleast three different bacterial species at different concentrations(MIC¼1250–5000lg/mL).Shigella flexneriwere the most affectedbacteria, but none of the compounds were effective against fun-gal isolate.
dc.description.sponsorshipArtvin Coruh University: 2019.F90.02.02
dc.identifier.citationAktas Kamiloglu, A., Direkel, S., Yalazan, H., Kantekin, H., & Acar, I. (2020). Octa-and tetra-substituted phthalocyanines with methoxyeugenol group: synthesis, characterization and in vitro antimicrobial activity. Journal of Coordination Chemistry, 73(7), 1177-1190en_US
dc.identifier.doi10.1080/00958972.2020.1761962
dc.identifier.endpage1190
dc.identifier.issue7
dc.identifier.scopusqualityQ3
dc.identifier.startpage1177
dc.identifier.startpage1177
dc.identifier.urihttps://hdl.handle.net/11494/2085
dc.identifier.volume73
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKamiloğlu Aktaş , Ayşe
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Coordination Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitak118Z578
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectOcta-phthalocyanineen_US
dc.subjectEugenolen_US
dc.subjectCharacterizationen_US
dc.subjectMetallophthalocyanineen_US
dc.subjectAnti-microbial activityen_US
dc.titleOcta- and tetra-substituted phthalocyanines with methoxyeugenol group: synthesis, characterization and in vitro antimicrobial activityen_US
dc.typeArticle

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