Synthesis, acetylcholinesterase, butyrylcholinesterase and tyrosinase inhibition, and antioxidant studies of 2-[2-(substituted-benzyl)-4(7)-phenyl-1H-benzimidazol-1-yl] acetohydrazides and methyl 2-[2-(substituted-benzyl)-4(7)-phenyl-1H-benzimidazol-1-yl] acetates
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Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bulgarian Academy of Sciences
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this research study we intend to synthesize six new 2-[2-(substituted-benzyl)-4(7)-phenyl-1H-benzimidazol-1-yl] acetohydrazides (8a-f) and six new methyl 2-[2-(substituted-benzyl)-4(7)-phenyl-1H-benzimidazol-1-yl] acetates (7a-f) with potency inhibiting acetylcholinesterase, butyrylcholinesterase and tyrosinase enzymes and antioxidant activities. The chemical structures of synthesized compounds were identified by IR, H-1-NMR, C-13-NMR, and elemental analysis. All these compounds were evaluated for their acetylcholinesterase, butyrylcholinesterase and tyrosinase enzymes inhibitory potentials and antioxidant activities. Biological activity results revealed that compounds 8f and 7c showed the highest tyrosinase inhibition with 52.46 +/- 2.67% and 52.32 +/- 0.70%, respectively. Compound 8f had the highest radical scavenging activities with 24.83 +/- 1.28% among the compounds whilst compound 8c showed the lowest activities with 9.62 +/- 0.85%. Compound 8f gave the highest PRAP and FRAP absorbance values with 0.180 +/- 0.013 and 0.358 +/- 0.009 at 100 mu M, respectively.
Açıklama
This research was financially supported by Artvin Coruh University Scientific Research Projects Fund (BAP-2016.F34.02.01).
3rd International Conference on New Trends in Chemistry
Location: Helsinki, FINLAND
Date: APR 28-30, 2017
Anahtar Kelimeler
Benzimidazoles, Tyrosinase, Acetylcholinesterase, Butyrylcholinesterase, Antioxidant activity
Kaynak
3rd International Conference on New Trends in Chemistry
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
49
Sayı
1
Künye
Gümüş, M., Doğan, İ., Barut, B., Özel, A., & Kahveci, B. (2017). Synthesis, acetylcholinesterase, butyrylcholinesterase and tyrosinase inhibition, and antioxidant studies of 2-[2-(substituted-benzyl)-4 (7)-phenyl-1H-benzimidazol-1-yl] acetohydrazides and methyl 2-[2-(substituted-benzyl)-4 (7)-phenyl-1H-benzimidazol-1-yl] acetates. 3rd International Conference on New Trends in Chemistry49, Bulgarian Chemical Communications(Özel Sayı: 1),107-114
