Synthesis, acetylcholinesterase, butyrylcholinesterase and tyrosinase inhibition, and antioxidant studies of 2-[2-(substituted-benzyl)-4(7)-phenyl-1H-benzimidazol-1-yl] acetohydrazides and methyl 2-[2-(substituted-benzyl)-4(7)-phenyl-1H-benzimidazol-1-yl] acetates

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dc.authorid0000-0001-6373-5221en_US
dc.contributor.authorGümüş, Mustafa Kemal
dc.contributor.authorDoğan, İnci Selin
dc.contributor.authorBarut, Burak
dc.contributor.authorÖzel, Arzu
dc.contributor.authorKahveci, Bahittin
dc.date.accessioned2021-04-15T09:44:03Z
dc.date.available2021-04-15T09:44:03Z
dc.date.issued2017
dc.departmentAÇÜ, Artvin Meslek Yüksekokulu, Laboratuvar Teknolojisi Bölümüen_US
dc.descriptionThis research was financially supported by Artvin Coruh University Scientific Research Projects Fund (BAP-2016.F34.02.01). 3rd International Conference on New Trends in Chemistry Location: Helsinki, FINLAND Date: APR 28-30, 2017en_US
dc.description.abstractIn this research study we intend to synthesize six new 2-[2-(substituted-benzyl)-4(7)-phenyl-1H-benzimidazol-1-yl] acetohydrazides (8a-f) and six new methyl 2-[2-(substituted-benzyl)-4(7)-phenyl-1H-benzimidazol-1-yl] acetates (7a-f) with potency inhibiting acetylcholinesterase, butyrylcholinesterase and tyrosinase enzymes and antioxidant activities. The chemical structures of synthesized compounds were identified by IR, H-1-NMR, C-13-NMR, and elemental analysis. All these compounds were evaluated for their acetylcholinesterase, butyrylcholinesterase and tyrosinase enzymes inhibitory potentials and antioxidant activities. Biological activity results revealed that compounds 8f and 7c showed the highest tyrosinase inhibition with 52.46 +/- 2.67% and 52.32 +/- 0.70%, respectively. Compound 8f had the highest radical scavenging activities with 24.83 +/- 1.28% among the compounds whilst compound 8c showed the lowest activities with 9.62 +/- 0.85%. Compound 8f gave the highest PRAP and FRAP absorbance values with 0.180 +/- 0.013 and 0.358 +/- 0.009 at 100 mu M, respectively.
dc.identifier.citationGümüş, M., Doğan, İ., Barut, B., Özel, A., & Kahveci, B. (2017). Synthesis, acetylcholinesterase, butyrylcholinesterase and tyrosinase inhibition, and antioxidant studies of 2-[2-(substituted-benzyl)-4 (7)-phenyl-1H-benzimidazol-1-yl] acetohydrazides and methyl 2-[2-(substituted-benzyl)-4 (7)-phenyl-1H-benzimidazol-1-yl] acetates. 3rd International Conference on New Trends in Chemistry49, Bulgarian Chemical Communications(Özel Sayı: 1),107-114en_US
dc.identifier.endpage114en_US
dc.identifier.issue1en_US
dc.identifier.startpage107en_US
dc.identifier.urihttps://hdl.handle.net/11494/3122
dc.identifier.volume49en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorGümüş, Mustafa Kemal
dc.language.isoenen_US
dc.publisherBulgarian Academy of Sciencesen_US
dc.relation.ispartof3rd International Conference on New Trends in Chemistry
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzimidazolesen_US
dc.subjectTyrosinaseen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectAntioxidant activityen_US
dc.titleSynthesis, acetylcholinesterase, butyrylcholinesterase and tyrosinase inhibition, and antioxidant studies of 2-[2-(substituted-benzyl)-4(7)-phenyl-1H-benzimidazol-1-yl] acetohydrazides and methyl 2-[2-(substituted-benzyl)-4(7)-phenyl-1H-benzimidazol-1-yl] acetatesen_US
dc.typeConference Object

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