Gallic acid reduces experimental colitis in rats by downregulation of cathepsin and oxidative stress

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dc.authorid0000-0003-2779-6478en_US
dc.authorid0000-0001-8567-807Xen_US
dc.authorid0000-0002-2223-1331en_US
dc.contributor.authorBayramoğlu, Gökhan
dc.contributor.authorŞentürk, Hakan
dc.contributor.authorKanbak, Güngör
dc.contributor.authorCanbek, Mediha
dc.contributor.authorBayramoğlu, Ayşegül
dc.contributor.authorDokumacıoğlu, Ali
dc.contributor.authorEngür, Selin
dc.date.accessioned2020-05-06T06:36:04Z
dc.date.available2020-05-06T06:36:04Z
dc.date.issued2020
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractObjective: Ulcerative colitis (UC) is an idiopathic inflammatory bowel disease (IBD) with common, repetitive inflammation of the colon and rectum, which is highly defined by loss of blood on colon mucosa, ulceration and acute inflammation. The present study aimed to investigate the potential protective effects of gallic acid (GA) through a 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis rat model, using biochemical and histopathological parameters. Materials and Methods: The study consisted of four groups, each including seven rats, namely control group, colitis group, colitis-GA 50 mg/kg group and colitis-GA 100 mg/kg group. Colon tissue samples were analyzed for malondialdehyde (MDA), myeloperoxidase (MPO), cathepsin B and cathepsin L values. Results: Tissue MDA, MPO, cathepsin L and cathepsin B values increased significantly in colitis group (p=0.028, p=0.038, p=0.024, p=0.019, respectively). However, MDA, MPO, cathepsin L and cathepsin B values showed a significant decrease in animals with GA (at a dose of 100 mg/kg) administration in TNBS-induced colitis in rats (p=0.021, p=0.026, p=0.019, p=0.031, respectively). Colitis group was defined by the severe detriment of surface epithelium, submucosal edema and inflammatory cell infiltration. Treatment with GA significantly decreased inflammatory cell infiltration. Conclusion: GA can be used as an effective agent in the treatment of colitis due to its inhibitory properties in multiple pathways and its potent antioxidant effects
dc.identifier.citationBayramoğlu, G., Şentürk, H., Kanbak, G., Canbek, M., Bayramoğlu, A., Dokumacıoğlu, E., Engür. S. (2020). Gallic Acid Reduces Experimental Colitis in Rats by Downregulation of Cathepsin and Oxidative Stress. Erciyes Medical Journal, 42(2): 213-217en_US
dc.identifier.doi10.14744/etd.2020.42713
dc.identifier.endpage127en_US
dc.identifier.issue2en_US
dc.identifier.startpage213en_US
dc.identifier.urihttps://hdl.handle.net/11494/2052
dc.identifier.volume42en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorBayramoğlu, Ayşegül
dc.institutionauthorBayramoğlu, Ayşegül
dc.institutionauthorBayramoğlu, Gökhan
dc.language.isoenen_US
dc.publisherErciyes Univ Sch Medicineen_US
dc.relation.ispartofErciyes Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/3.0/us/*
dc.subjectCathepsinen_US
dc.subjectcolitisen_US
dc.subjectgallic aciden_US
dc.subjectmyleperoxidaseen_US
dc.subjectoxidative stressen_US
dc.titleGallic acid reduces experimental colitis in rats by downregulation of cathepsin and oxidative stressen_US
dc.typeArticle

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