Evaluating the toxic and beneficial effects of lichen extracts in normal and diabetic rats

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dc.contributor.authorÇolak, Suat
dc.contributor.authorGeyikoğlu, Fatime
dc.contributor.authorTürkez, Hasan
dc.contributor.authorAslan, Ali
dc.date.accessioned2020-11-12T07:04:50Z
dc.date.available2020-11-12T07:04:50Z
dc.date.issued2016
dc.departmentAÇÜ, Rektörlüken_US
dc.description.abstractLichens can be used as a novel bioresource for natural antioxidants. However, there is need for further investigations to validate the lichens used in medicinal remedies. In this study, the effects of Cetraria islandica and Pseudevernia furfuracae lichen species in streptozotocin (STZ)-induced diabetes were evaluated. Diabetic rats were treated with aqueous lichen extracts (250 and 500 mg/kg/day) for 2 weeks starting at 72 h after STZ injection. On the 14th day, animals were anesthetized, and then metabolic and biochemical parameters were evaluated between control and treatment groups. Pancreatic histology and -cell mass were examined by hematoxylin and eosin and insulin immunohistochemistry stainings. Our findings revealed that these lichen species could be used safely in this dose range. In addition, C. islandica extracts showed prominent results compared to the doses of P. furfuracae extract for antioxidant capacity. However, the protectivity of C. islandica extract was inadequate against diabetes-induced pancreatic damages via forming oxidative stress. In conclusion, the usage of C. islandica might serve for early intervening in the risk reduction of type 1 diabetes.
dc.description.sponsorshipThis work was supported by Ataturk University Research Foundation.en_US
dc.identifier.citationÇolak, S., Geyikoğlu, F., Bakır, T. Ö., Türkez, H., & Aslan, A. (2016). Evaluating the toxic and beneficial effects of lichen extracts in normal and diabetic rats. Toxicology and Industrial Health, 32(8), 1495-1504.en_US
dc.identifier.doi10.1177/0748233714566873
dc.identifier.endpage1504en_US
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage1495en_US
dc.identifier.urihttps://hdl.handle.net/11494/2442
dc.identifier.volume32en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇolak, Suat
dc.language.isoenen_US
dc.publisherSage Publicationsen_US
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCetraria islandicaen_US
dc.subjectPseudevernia furfuracaeen_US
dc.subjectDiabetes mellitusen_US
dc.subjectPancreasen_US
dc.subjectHistologyen_US
dc.subjectOxidative stressen_US
dc.titleEvaluating the toxic and beneficial effects of lichen extracts in normal and diabetic ratsen_US
dc.typeArticle

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