The effect of Echinacea on kidney and liver after experimental renal ischemia/reperfusion injury in the rats

Basit Öğe Kaydı
dc.authorid0000-0001-6800-5607en_US
dc.authorid0000-0002-1120-1874en_US
dc.contributor.authorBayramoğlu, Gökhan
dc.contributor.authorKabay, Şahin
dc.contributor.authorÖzden, Hilmi
dc.contributor.authorÜstüner, Mehmet Cengiz
dc.contributor.authorUysal, Onur
dc.contributor.authorBayramoğlu, Ayşegül
dc.contributor.authorŞentürk, Hakan
dc.contributor.authorGüven, Gül
dc.contributor.authorÖzbayar, Cansu
dc.contributor.authorKutlu, Ali
dc.contributor.authorÜstüner, Derya
dc.contributor.authorCanbek, Mediha
dc.date.accessioned2020-01-06T10:05:36Z
dc.date.available2020-01-06T10:05:36Z
dc.date.issued2011
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.description.abstractThe aim of the study is to investigate the effect of Echinacea on kidney and liver against oxidative stress during renal ischemia-reperfusion (I/R) injury, by determining biochemical parameters and evaluating histological examinations. Adult male Sprague-Dawley rats were evaluated in five groups (each group consists of 8 animals). Group 1 (Control; non-ischemic animals); Group 2 (renal I/R injury+Saline), Group 3 (renal I/R injury + Echinacea, 25 mg/kg), Group 4 (renal I/R injury + Echinacea, 50 mg/kg) Group 5 (renal I/R injury+ Echinacea, 100 mg/kg) were designed to evaluate effects of Echinacea in renal I/R injury on the morphological changes in kidney and liver. A right nephrectomy was performed for I/R injury. On the 15th day following nephrectomy, ischemia and reperfusion was performed. Echinacea was administered intraperitoneally. Left kidney and liver were taken after 24 h of reperfusion period for histopathological examinations. The malondialdehyde (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) enzyme activities were determined from tissue homogenates. In the study, Echinacea administration in renal ischemia-reperfusion decreased MDA in kidney and liver. SOD activity was decreased with low and high doses of Echinacea treatment in both kidney and liver. Echinacea administration decreased CAT levels in kidney and no difference was observed between Echinacea doses. CAT was increased in liver low dose group. But CAT was decreased in high doses of Echinacea. Histopathological examinations showed partial improvement in the damages seen in I/R injury after Echinacea administration at both kidney and liver. Echinacea may be effective in preventing oxidative injury.
dc.identifier.citationBayramoglu, G., Kabay, S., Ozden, H., Ustuner, M. C., Uysal, O., Bayramoglu, A., ... & Canbek, M. (2011). The effect of Echinacea on kidney and liver after experimental renal ischemia/reperfusion injury in the rats. African Journal of Pharmacy and Pharmacology, 5(13), 1561-1566.en_US
dc.identifier.doi10.5897/AJPP11.025
dc.identifier.endpage1566en_US
dc.identifier.issue13en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage1561en_US
dc.identifier.urihttps://hdl.handle.net/11494/1912
dc.identifier.volume5en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÜstüner, Mehmet Cengiz
dc.institutionauthorBayramoğlu, Ayşegül
dc.institutionauthorÖzbayar, Cansu
dc.institutionauthorBayramoğlu, Gökhan
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.relation.ispartofAfrican Journal Of Pharmacy And Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEchinaceaen_US
dc.subjectIschemia-reperfusionen_US
dc.subjectKidneyen_US
dc.subjectLiveren_US
dc.subjectAntioxidant enzymeen_US
dc.titleThe effect of Echinacea on kidney and liver after experimental renal ischemia/reperfusion injury in the ratsen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
gokhan.bayramoglu.pdf
Boyut:
3.55 MB
Biçim:
Adobe Portable Document Format
Açıklama:
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Artvin MYO Koleksiyonu Yayın Koleksiyonu
Beslenme ve Diyetetik Bölümü Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu