Protective effects of curcumin against valproic acid induced brain kidney and liver damage in rats

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dc.contributor.authorTerim Kapakin, Kübra Asena
dc.contributor.authorBolat, İsmail
dc.contributor.authorİskender, Hatice
dc.contributor.authorDokumacioğlu, Eda
dc.contributor.authorManavoğlu Kirman, Esra
dc.contributor.authorBolat, Merve
dc.contributor.authorGül, Mevlana
dc.date.accessioned2024-11-26T10:22:14Z
dc.date.available2024-11-26T10:22:14Z
dc.date.issued2024
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractValproic acid (VPA) is a broad-spectrum drug that is now widely used as an antiepileptic. Although VPA has positive therapeutic effects, it also causes various toxic effects in tissues. Curcumin, a natural antioxidant found in ginger, has antibacterial and antiinflammatory activity. In this study, the toxic effects of VPA on brain, kidney, and liver tissues and the protective activity of curcumin against these effects were investigated. In this study, male Wistar-Albino rats were used. Rats were divided into 4 groups control, VPA, CUR, and CUR + VPA. Rats were administered intraperitoneal VPA and CUR intragastrically. In the study, MDA, SOD, IL-6, and IL-18 levels were measured by the ELISA method in rats. It was observed that VPA triggered oxidative stress and inflammation in tissues, while CUR administration positively regulated these parameters. Studies also showed that VPA increased the expressions of TNF-? and NF-kB in tissues, but CUR administration downregulated these expressions The findings revealed that CUR protects by preventing the oxidative stress and inflammation caused by VPA in the tissues and may be an important agent in reducing the side effects of this drug used as an antiepileptic.
dc.identifier.doi10.1080/01480545.2024.2391868
dc.identifier.issn0148-0545
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1080/01480545.2024.2391868
dc.identifier.urihttps://hdl.handle.net/11494/5023
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofDrug and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectBrainen_US
dc.subjectCurcuminen_US
dc.subjectKidneyen_US
dc.subjectLiveren_US
dc.subjectValproic Aciden_US
dc.titleProtective effects of curcumin against valproic acid induced brain kidney and liver damage in ratsen_US
dc.typeArticle

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