The effect of white tea on serum TNF-α/NF-κB and immunohistochemical parameters in cisplatin-related renal dysfunction in female rats

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dc.authorid0000-0002-2223-1331en_US
dc.contributor.authorSaral, Sinan
dc.contributor.authorDokumacıoğlu, Eda
dc.contributor.authorMercantepe, Tolga
dc.contributor.authorAtak, Mehtap
dc.contributor.authorÇınar, Seda
dc.contributor.authorSaral, Özlem
dc.contributor.authorYıldız, Lamiye
dc.contributor.authorİskender, Hatice
dc.contributor.authorTumkaya, Levent
dc.date.accessioned2020-11-05T07:46:00Z
dc.date.available2020-11-05T07:46:00Z
dc.date.issued2019
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.descriptionThe study was funded by a grant from the scientific research foundation of Recep Tayyip Erdogan University .en_US
dc.description.abstractObjective: Nephrotoxicity is the most important side effect of the antineoplastic drug cisplatin, thereby restricting its use. The aim of this study was to investigate the protective effects of white tea infusions (WT) against renal damage induced by cisplatin (CP) in rats by biochemical and histopathological means. Materials and methods: This study used 24 female Sprague Dawley rats at 12–14 weeks of age and weighing 250–300 g. Rats were divided into three groups: Control, CP and CP + WT groups. CP was injected 7 mg/kg i.p as a single dose/rat in the CP group. White tea was given at a dose of 0.5% (w/v) for 4 weeks. At the end of the experiment, blood urea nitrogen (BUN), creatinine, uric acid, tumor necrosis factor-alpha (TNF-?), interleukin-6 (IL-6) and nuclear factor kappa B (NF-?B) along with caspase-3 in the kidney were evaluated in study. Results: BUN, creatinine, TNF-? NF-?B and IL-6 levels of the CP group showed a statisically significant increase in comparison to the control group. TNF-? NF-?B and IL-6 levels showed a statistically significant decrease in the CP + WT group with respect to the CP group. Caspase-3 levels in tubular epithelial cells decreased in CP + WT group compared with CP group (p = 0.02). Conclusion: White tea infusions reduced significantly the nephrotoxicity of CP. The anti-nephrotoxic feature of the infusion may be attributed primarily to its anti-inflammatory and anti-apoptotic characteristics.
dc.identifier.citationSaral, S., Dokumacıoğlu, E., Mercantepe, T., Atak, M., Çınar, S., Saral, O., ... & Tumkaya, L. (2019). The effect of white tea on serum TNF-α/NF-κB and immunohistochemical parameters in cisplatin-related renal dysfunction in female rats. Biomedicine & Pharmacotherapy, 112, 108604.en_US
dc.identifier.doi10.1016/j.biopha.2019.108604
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/11494/2412
dc.identifier.volume112en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorİskender, Hatice
dc.institutionauthorDokumacıoğlu, Eda
dc.language.isoenen_US
dc.publisherElsevier Masson SASen_US
dc.relation.ispartofBiomedicine and Pharmacotherapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTeaen_US
dc.subjectRenal damageen_US
dc.subjectNF-κBen_US
dc.subjectTNF-αen_US
dc.subjectCaspase-3en_US
dc.subjectCisplatinen_US
dc.titleThe effect of white tea on serum TNF-α/NF-κB and immunohistochemical parameters in cisplatin-related renal dysfunction in female ratsen_US
dc.typeArticle

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