The effect of bee pollen on reproductive and biochemical parameters in methotrexate-induced testicular damage in adult rats

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dc.authorid0000-0002-2223-1331en_US
dc.authorid0000-0002-0961-1903en_US
dc.contributor.authorSaral, Özlem
dc.contributor.authorDokumacıoğlu, Eda
dc.contributor.authorSaral, Sinan
dc.contributor.authorSümer, Ayşegül
dc.contributor.authorBulmuş, Özgür
dc.contributor.authorÖzer Kaya, Şeyma
dc.contributor.authorCanpolat, Sinan
dc.date.accessioned2021-01-05T09:33:02Z
dc.date.available2021-01-05T09:33:02Z
dc.date.issued2020
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.description.abstractMethotrexate (MTX) is an anticancer drug used in chemotherapy. MTX was known for its toxic effects involving most of the organs including testis. Bee pollen is healthy food for human and has antioxidant effect. We intended to determine protective effect of bee pollen against testicular injury caused by MTX in rats. Thirty-two adult Sprague Dawley male rats were used, and 4 groups were formed: control, MTX, pollen, and MTX + pollen. Rats were given pollen at a dose of 400 mg/kg with intragastric gavage for 10 days. On day 7, MTX was administered a single dose of 30 mg/kg ip. Serum testosterone and LH, tissue MDA level, and SOD and CAT enzyme activities were examined. In addition, spermatological parameters were evaluated. MDA level and SOD activity increased while testosterone level decreased significantly in the MTX group compared to the control group. In the MTX + pollen group, MDA level and SOD activity decreased while testosterone level increased. There was no significant change in CAT activity and LH values. Abnormal sperm ratio decreased in the MTX + pollen group compared to the MTX group. Our results suggest that bee pollen has a healing effect on reproductive parameters in testicular damage caused by MTX.
dc.description.sponsorshipThis project was supported by Recep Tayyip Erdogan University Scientific Research Projects Coordination Unit. Thanks to Macahel Apiculture Co. Ltd. which has helped us to supply bee pollen. Research funding: This project was supported by Recep Tayyip Erdogan University Scientific Research Projects Coordination Unit (RTEUBAP).en_US
dc.identifier.citationSaral, O., Dokumacıoğlu, E., Saral, S., Sümer, A., Bulmuş, O., Kaya, S. O., & Canpolat, S. (2020). The effect of bee pollen on reproductive and biochemical parameters in methotrexate-induced testicular damage in adult rats. Journal of Basic and Clinical Physiology and Pharmacology,en_US
dc.identifier.doi10.1515/jbcpp-2020-0152
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1515/jbcpp-2020-0152
dc.identifier.urihttps://hdl.handle.net/11494/2518
dc.identifier.volumeArticle in Press
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDokumacıoğlu, Eda
dc.language.isoenen_US
dc.publisherDe Gruyter Open Ltden_US
dc.relation.ispartofJournal of Basic and Clinical Physiology and Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethotrexateen_US
dc.subjectOxidative stressen_US
dc.subjectPollenen_US
dc.subjectTesticular damageen_US
dc.subjectTestosteroneen_US
dc.titleThe effect of bee pollen on reproductive and biochemical parameters in methotrexate-induced testicular damage in adult ratsen_US
dc.typeArticle

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