Inhibition of human carbonic anhydrase isozymes I, II and VI with a series of bisphenol, methoxy and bromophenol compounds

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dc.authorid0000-0002-0426-0905en_US
dc.authorid0000-0001-5968-7511en_US
dc.contributor.authorBalaydın, Halis Türker
dc.contributor.authorDurağı, Serdar
dc.contributor.authorEkinci, Deniz
dc.contributor.authorŞentürk, Murat
dc.contributor.authorGöksoy, Süleyman
dc.contributor.authorMenzek, Abdullah
dc.date.accessioned2020-11-16T08:11:34Z
dc.date.available2020-11-16T08:11:34Z
dc.date.issued2012
dc.departmentAÇÜ, Eğitim Fakültesien_US
dc.description.abstractCarbonic anhydrase inhibitors (CAI) are valuable molecules as they have several therapeutic applications, including anti-glaucoma activity. In this study, inhibition of three human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I, II and VI with a series of bisphenol and bromophenol derivatives was investigated. Molecular docking studies of a set of such inhibitors within CA I and II were also performed. K-I values of the molecules 2-9 were in the range of 10.025-892.109 mu M for hCA I, 1.437-59.107 mu M for hCA II and 11.143-919.182 mu M for hCA VI, respectively. Reported inhibitory activities of molecules 2-9 will assist in better understanding of structure-activity relationship studies of CAI.
dc.description.sponsorshipThis study was financed by Turkish Republic Prime Ministry State Planning Organization (DPT), (project no: 2010K120440) and Agri Ibrahim Cecen University Scientific Research Council, (project no: Agri BAP-2010/K-10) for (MS) and by the Scientific and Technological Research Council of Turkey (TUBITAK, Grant No: TBAG-107T/348) for (SG, HTB and AM).en_US
dc.identifier.citationBalaydın, H. T., Durdağı, S., Ekinci, D., Şentürk, M., Göksu, S., & Menzek, A. (2012). Inhibition of human carbonic anhydrase isozymes I, II and VI with a series of bisphenol, methoxy and bromophenol compounds. Journal of Enzyme Inhibition and Medicinal Chemistry, 27(4), 467-475.en_US
dc.identifier.doi10.3109/14756366.2011.596836
dc.identifier.endpage475en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage467en_US
dc.identifier.urihttps://hdl.handle.net/11494/2461
dc.identifier.volume27en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBalaydın, Halis Türker
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitakTBAG-107T/348
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectMolecular dockingen_US
dc.subjectBisphenolen_US
dc.subjectBromophenolen_US
dc.subjecthCA IIen_US
dc.subjecthCA VIen_US
dc.titleInhibition of human carbonic anhydrase isozymes I, II and VI with a series of bisphenol, methoxy and bromophenol compoundsen_US
dc.typeArticle

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