In vitro, anti-colon cancer activity of green dumbbell-shaped rhododendron luteum-based carbon dots

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dc.contributor.authorDurmaz, Alper
dc.contributor.authorMizan Kahyaoğlu, İbrahim
dc.contributor.authorCan Aytar, Erdi
dc.contributor.authorDanışmaSert, Esran Kalındemirtaş, Ferdane
dc.contributor.authorErol Bozkurt, Ayşe
dc.contributor.authorKarakuş, Selcan
dc.date.accessioned2025-06-22T14:27:50Z
dc.date.available2025-06-22T14:27:50Z
dc.date.issued2025
dc.departmentAÇÜ
dc.description.abstractColorectal cancer is the second most common cause of cancer-related deaths worldwide and the third most common cancer overall. In this study, we investigate the anti-colon cancer potential of phytochemically, and thermally synthesised novel green carbon dots based on Rhododendron luteum (RL-CDs). A new synthesis method was used to produce carbon dots obtained from the Rhododendron luteum (RL) plant in an environmentally friendly manner. The green RL were characterized using Fourier-transform infrared spectroscopy (FTIR), UV-Vis spectroscopy, transmission electron microscopy (TEM), and artificial intelligence (AI)-based TEM analysis. The FTIR spectrum showed peaks corresponding to the hydroxyl (−OH) vibration of polyphenols at 3500 cm⁻¹, the C=O vibration of cellulose derivatives at 1728 cm⁻¹, and the C−O stretching of primary alcohol at 1041 cm⁻¹. Two UV absorption peaks at roughly 253 nm (UV−C range), and 320 nm (UV−B range) were observed. The size of the green RL was measured to be less than 50 nm, and its morphology was characterized as dumbbell-shaped through TEM analysis. In-vitro studies were performed with HCT116 colon cancer, MCF-7 breast cancer, and normal HUVEC cells. The results demonstrated that the RL-CDs exhibited selective cytotoxic activity against HCT116 colon cancer cells. The results show that the RL extract stimulates cancer cell death by decreasing the CD44/24 ratio, and increasing apoptotic activity. These observations suggest that green RL-CDs could be an effective anticancer agent in colon cancer therapy, investigating their potential in this direction could be a promising way for future research.
dc.identifier.doi10.1002/open.202400303
dc.identifier.issn21911363
dc.identifier.issue5
dc.identifier.pmid39888200
dc.identifier.scopus2-s2.0-85216345739
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/11494/5579
dc.identifier.volume14
dc.identifier.wosWOS:001408930200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorDurmaz, Alper
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofChemistryOpen
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnticancer
dc.subjectGreen nanostructure
dc.subjectHCT116 colon cancer cell
dc.subjectMCF-7 breast cancer
dc.subjectRhododendron luteum
dc.titleIn vitro, anti-colon cancer activity of green dumbbell-shaped rhododendron luteum-based carbon dots
dc.typeArticle

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