Effects of oleanolic acid on inflammation and metabolism in diabetic rats

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dc.authorid0000-0002-8063-4972en_US
dc.authorid0000-0002-2223-1331en_US
dc.contributor.authorİskender, Hatice
dc.contributor.authorDokumacıoğlu, Eda
dc.contributor.authorTerim Kapakın, Kübra Asena
dc.contributor.authorYenice, Güler
dc.contributor.authorMohtare, Behzat
dc.contributor.authorBolat, İsmail
dc.contributor.authorHayırlı, Armağan
dc.date.accessioned2021-08-09T08:23:52Z
dc.date.available2021-08-09T08:23:52Z
dc.date.issued2021
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.descriptionThis work was supported by Coordinator of Scientific Research Projects [2018.M83.02.02] at Artvin Coruh University.en_US
dc.description.abstractDiabetes mellitus (DM) is a chronic metabolic disease that threatens the health of the world population. We investigated the effects of oleanolic acid (OA) administration on inflammation status and metabolic profile in streptozotocin (STZ) induced diabetic rats. Four experimental groups were established: healthy rats not administered OA, healthy rats administered OA, diabetic rats not administered OA, diabetic rats administered OA. OA, 5 mg/kg, was administered by oral gavage for 21 days. Serum samples collected at the end of the experiment and analyzed for toll-like receptor-9, interleukin-18, nuclear factor kappa B, malondialdehyde MDA, glucose, total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, calcium, phosphorus, magnesium and potassium. Pancreas tissue was examined for pathology. Induction of DM caused increased serum concentrations of inflammation and oxidative damage markers. DM also caused hyperglycemia-hyperlipidemia and decreased serum concentration of minerals. The islets of Langerhans were degenerated and necrotic. Administration of OA reversed the adverse effects of DM. OA treatment can ameliorate inflammation and oxidative damage due to DM by normalizing hyperglycemia and decreasing TLR-9, IL-18, NF-kappa B and MDA levels.
dc.identifier.citationİskender, H., Dokumacıoğlu, E., Terim Kapakın, K. A., Yenice, G., Mohtare, B., Bolat, I., & Hayırlı, A. (2021). Effects of oleanolic acid on inflammation and metabolism in diabetic rats. Biotechnic & Histochemistry.en_US
dc.identifier.doi10.1080/10520295.2021.1954691
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/11494/3314
dc.identifier.volumeArticle in presen_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorİskender, Hatice
dc.institutionauthorDokumacıoğlu, Eda
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofBiotechnic and Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectIL-18en_US
dc.subjectinflammation NF-kappa Ben_US
dc.subjectoleanolic aciden_US
dc.subjectratsen_US
dc.subjectTLR-9en_US
dc.titleEffects of oleanolic acid on inflammation and metabolism in diabetic ratsen_US
dc.typeArticle

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