Syntheses and biological activities of new hybrid molecules containing different heterocyclic moieties
Yükleniyor...
Dosyalar
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-VCH Verlag GmbH
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
4-Aryl-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-(thi)oles 5-7, obtained starting from nicotinic acid hydrazide were converted to the corresponding Mannich bases 12-24 by the reaction with several heterocyclic amines in the presence of formaldehyde. The synthesis of S-alkylated compounds 8-11 was performed from the reaction of the corresponding triazol-5-thioles with various alkyl halides. The condensation of carbo(thio)amides 2-4 with 4-chlorophenacyl bromide afforded the corresponding 1,3-thia(oxa)zol-2(3H)-ylidene]pyridine-3-carbohydrazides 25-27. 1,3-Thia(oxa)zolidine derivatives 28-30 were obtained from the cyclization reaction between compounds 2-4 and ethyl bromoacetate. All newly synthesized compounds were screened for their antimicrobial, antiurease, and antilipase activities. The biological activity studies revealed that all the compounds screened showed good or moderate antimicrobial, antiurease, and/or antilipase activity.
Açıklama
Anahtar Kelimeler
Biological activity, Nicotinic acid hydrazide, 1,3-Thia(oxa)zole, 1,3-Thia(oxa)zolidinone, 1,2,4-Triazole
Kaynak
Archiv der Pharmazie
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
346
Sayı
10
Künye
Ceylan, S., Bektas, H., Bayrak, H., Demirbas, N., Alpay‐Karaoglu, S., & Ülker, S. (2013). Syntheses and biological activities of new hybrid molecules containing different heterocyclic moieties. Archiv der Pharmazie, 346(10), 743-756.
