Syntheses and biological activities of new hybrid molecules containing different heterocyclic moieties

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dc.authorid0000-0003-1047-8350en_US
dc.contributor.authorCeylan, Şule
dc.contributor.authorBektaş, Hakan
dc.contributor.authorBayrak, Hacer
dc.contributor.authorDemirbaş, Neslihan
dc.contributor.authorAlpay Karaoğlu, Şengül
dc.contributor.authorÜlker, Serdar
dc.date.accessioned2020-11-10T07:46:17Z
dc.date.available2020-11-10T07:46:17Z
dc.date.issued2013
dc.departmentAÇÜ, Orman Fakültesien_US
dc.description.abstract4-Aryl-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-(thi)oles 5-7, obtained starting from nicotinic acid hydrazide were converted to the corresponding Mannich bases 12-24 by the reaction with several heterocyclic amines in the presence of formaldehyde. The synthesis of S-alkylated compounds 8-11 was performed from the reaction of the corresponding triazol-5-thioles with various alkyl halides. The condensation of carbo(thio)amides 2-4 with 4-chlorophenacyl bromide afforded the corresponding 1,3-thia(oxa)zol-2(3H)-ylidene]pyridine-3-carbohydrazides 25-27. 1,3-Thia(oxa)zolidine derivatives 28-30 were obtained from the cyclization reaction between compounds 2-4 and ethyl bromoacetate. All newly synthesized compounds were screened for their antimicrobial, antiurease, and antilipase activities. The biological activity studies revealed that all the compounds screened showed good or moderate antimicrobial, antiurease, and/or antilipase activity.
dc.description.sponsorshipKaradeniz Technical University: 8623 8663en_US
dc.identifier.citationCeylan, S., Bektas, H., Bayrak, H., Demirbas, N., Alpay‐Karaoglu, S., & Ülker, S. (2013). Syntheses and biological activities of new hybrid molecules containing different heterocyclic moieties. Archiv der Pharmazie, 346(10), 743-756.en_US
dc.identifier.doi10.1002/ardp.201300161
dc.identifier.endpage756en_US
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage743en_US
dc.identifier.urihttps://hdl.handle.net/11494/2435
dc.identifier.volume346en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorCeylan, Şule
dc.language.isoenen_US
dc.publisherWiley-VCH Verlag GmbHen_US
dc.relation.ispartofArchiv der Pharmazie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiological activityen_US
dc.subjectNicotinic acid hydrazideen_US
dc.subject1,3-Thia(oxa)zoleen_US
dc.subject1,3-Thia(oxa)zolidinoneen_US
dc.subject1,2,4-Triazoleen_US
dc.titleSyntheses and biological activities of new hybrid molecules containing different heterocyclic moietiesen_US
dc.typeArticle

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