Measuring urinary 8-hydroxy-2'-deoxyguanosine and malondialdehyde levels in women with overactive bladder

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dc.authorid0000-0002-2223-1331en_US
dc.contributor.authorDokumacıoğlu, Eda
dc.contributor.authorDemiray, Özay
dc.contributor.authorDokumacıoğlu, Ali
dc.contributor.authorŞahin, Arzu
dc.contributor.authorŞen, Tuğba Mazlum
dc.contributor.authorCankaya, Mazlum
dc.date.accessioned2020-06-29T11:55:07Z
dc.date.available2020-06-29T11:55:07Z
dc.date.issued2018
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.description.abstractPurpose: In this study, we aimed to explain the role of oxidative stress in women with overactive bladder (OAB) by investigating the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, and malondialdehyde (MDA), an indicator of lipid peroxidation. Materials and Methods: A total of 90 women were included in the study: 45 female patients diagnosed with OAB at Hopa State Hospital Urology Polyclinic and 45 healthy women without any metabolic or neurologic disease. Levels of MDA and 8-OHdG were measured in 24-hour urine samples for all subjects. Results: Urinary levels of MDA and 8-OHdG were significantly higher in the OAB group than in the control group (p<0.001). A significant positive correlation (p<0.001) was found between the measurements of 8-OHdG and MDA. Conclusions: Oxidative stress may be important in the pathophysiology of OAB, because levels of 8-OHdG and MDA are increased. Increased levels of 8-OHdG may be due to damaged nuclear and mitochondrial DNA as a result of oxidative attacks caused by free radicals. Nevertheless, further randomized and prospective studies with larger patient populations are needed
dc.description.sponsorshipThis work was supported by Coordinator of Scientific Research Projects (2015.M80.02.04) at Artvin Coruh University.en_US
dc.identifier.citationDokumacıoğlu, E., Demiray, O., Dokumacıoğlu, A., Şahin, A., Şen, T. M., & Cankaya, S. (2018). Measuring urinary 8-hydroxy-2′-deoxyguanosine and malondialdehyde levels in women with overactive bladder. Investigative and Clinical Urology, 59(4), 252-256.en_US
dc.identifier.doi10.4111/icu.2018.59.4.252
dc.identifier.endpage256en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage252en_US
dc.identifier.urihttps://hdl.handle.net/11494/2132
dc.identifier.volume59en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDokumacıoğlu, Eda
dc.language.isoenen_US
dc.publisherKorean Urological Assocen_US
dc.relation.ispartofInvestigative and Clinical Urology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectLipid peroxidationen_US
dc.subjectOxidative stressen_US
dc.subjectUrinary bladderen_US
dc.subjectoveractiveen_US
dc.subject8OHdGen_US
dc.titleMeasuring urinary 8-hydroxy-2'-deoxyguanosine and malondialdehyde levels in women with overactive bladderen_US
dc.typeArticle

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