Chlorine-thymol substituted silicon (IV) phthalocyanines: Synthesis, characterization, and in vitro acetylcholinesterase (AChE)/butyrylcholinesterase (BChE) inhibitory effect
Yükleniyor...
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
John Wiley and Sons Ltd
Erişim Hakkı
info:eu-repo/semantics/embargoedAccess
Özet
In this study, novel chlorine-thymol derivatives (1,3-bis(4-chloro-2-isopropyl-5 methylphenoxy)propan-2-ol (Thy-OHI) and 2-[2-(4-chloro-2-isopropyl-5-methylphenoxy)ethoxy]ethanol (Thy-OHII)) and axially di-4-chloro-2-isopropyl-5-methylphenoxy (Thy-SiPc), 1,3-bis(4-chloro-2-isopropyl-5-methylphenoxy)propanoxy (Thy-OHI-SiPc), and 2-[2-(4-chloro-2-isopropyl-5-methylphenoxy)ethoxy]ethanoxy (Thy-OHII-SiPc) substituted silicon phthalocyanine compounds were obtained, and their structures were elucidated by the combination of various methods such as NMR, IR, UV–Vis, and MS. The inhibitory effects of these compounds (Thy-OHI, Thy-OHII, Thy-SiPc, Thy-OHI-SiPc and Thy-OHII-SiPc), synthesized for the first time, on cholinesterase enzymes (AChE and BChE) were investigated in the laboratory environment. In the studies, notably Thy-OHI-Si and thymol derivative ligand Thy-OHII displayed significant inhibition against AChE and BChE.
Açıklama
Anahtar Kelimeler
Acetylcholinesterase, Alzheimer's Disease, Butyrylcholinesterase, Silicon Phthalocyanine, Thymol
Kaynak
Applied Organometallic Chemistry
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
