Chlorine-thymol substituted silicon (IV) phthalocyanines: Synthesis, characterization, and in vitro acetylcholinesterase (AChE)/butyrylcholinesterase (BChE) inhibitory effect

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dc.authorid0000-0002-7347-4018en_US
dc.authorid0000-0002-1426-5857en_US
dc.authorid0000-0002-0362-9387en_US
dc.authorid0000-0003-2625-2815en_US
dc.contributor.authorAktaş Kamiloğlu, Ayşe
dc.contributor.authorArslan, Tayfun
dc.contributor.authorTekin, Aşkın
dc.contributor.authorKantekin, Halit
dc.contributor.authorAcar, İrfan
dc.date.accessioned2024-11-21T11:00:14Z
dc.date.available2024-11-21T11:00:14Z
dc.date.issued2024
dc.departmentAÇÜ, Artvin Meslek Yüksekokulu, Laboratuvar Teknolojisi Bölümüen_US
dc.description.abstractIn this study, novel chlorine-thymol derivatives (1,3-bis(4-chloro-2-isopropyl-5 methylphenoxy)propan-2-ol (Thy-OHI) and 2-[2-(4-chloro-2-isopropyl-5-methylphenoxy)ethoxy]ethanol (Thy-OHII)) and axially di-4-chloro-2-isopropyl-5-methylphenoxy (Thy-SiPc), 1,3-bis(4-chloro-2-isopropyl-5-methylphenoxy)propanoxy (Thy-OHI-SiPc), and 2-[2-(4-chloro-2-isopropyl-5-methylphenoxy)ethoxy]ethanoxy (Thy-OHII-SiPc) substituted silicon phthalocyanine compounds were obtained, and their structures were elucidated by the combination of various methods such as NMR, IR, UV–Vis, and MS. The inhibitory effects of these compounds (Thy-OHI, Thy-OHII, Thy-SiPc, Thy-OHI-SiPc and Thy-OHII-SiPc), synthesized for the first time, on cholinesterase enzymes (AChE and BChE) were investigated in the laboratory environment. In the studies, notably Thy-OHI-Si and thymol derivative ligand Thy-OHII displayed significant inhibition against AChE and BChE.
dc.identifier.doi10.1002/aoc.7757
dc.identifier.issn0268-2605
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1002/aoc.7757
dc.identifier.urihttps://hdl.handle.net/11494/4991
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Ltden_US
dc.relation.ispartofApplied Organometallic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectSilicon Phthalocyanineen_US
dc.subjectThymolen_US
dc.titleChlorine-thymol substituted silicon (IV) phthalocyanines: Synthesis, characterization, and in vitro acetylcholinesterase (AChE)/butyrylcholinesterase (BChE) inhibitory effecten_US
dc.typeArticle

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