Phytochemical analysis, radical scavenging activity, and molecular docking studies of heliotropium sibiricum (L.) J.I.M.melo
| dc.contributor.author | Durmaz, Alper | |
| dc.contributor.author | Aytar, Erdi Can | |
| dc.contributor.author | Aydın, Betül | |
| dc.contributor.author | İncilay Torunoğlu, Emine | |
| dc.contributor.author | Solmaz, Fatma Gönül | |
| dc.contributor.author | Viana, Altevir Rossato | |
| dc.contributor.author | Çolak, Ayşen Melda | |
| dc.contributor.author | Flores, Erico Marlon Moraes | |
| dc.date.accessioned | 2025-06-23T08:08:55Z | |
| dc.date.available | 2025-06-23T08:08:55Z | |
| dc.date.issued | 2025 | |
| dc.department | AÇÜ | |
| dc.description.abstract | This study explores the phytochemical profile and molecular docking properties of Heliotropium sibiricum (L.) J.I.M.Melo, as detailed in Kew Bull. 77: 970 (2022). Antioxidant assays revealed strong radical scavenging activity (DPPH: 0.14 ± 0.02 μg/mL) and moderate iron chelation capacity (4.23 ± 0.99 mg/mL). The extract exhibited high phenolic (393.79 ± 30.14 μg/mL) and flavonoid (50.76 ± 1.40 μg/mL) contents. Enzymatic antioxidant assays showed notable activities: MDA (0.2141 ± 0.0047 μM), CAT (426 ± 14.73 U/mg), PO (8.366 ± 0.15 U/mg), SOD (53.13 ± 1.41 U/mg), and Mn-SOD (7.63 ± 0.31 U/mg). GC–MS analysis identified major compounds including pyrrolidine (15.08%), neophytadiene (9.40%), 9,12,15-octadecatrienoic acid (9.75%), and 2-pentadecanone, 6,10,14-trimethyl- (7.19%). Molecular docking revealed binding energies ranging from −3.4 to −5.2 kcal/mol, with 1,2-cyclohexanedimethanol showing the strongest interaction. These results demonstrate the plant's significant antioxidant potential and suggest that its bioactive constituents may serve as promising candidates for pharmacological development. | |
| dc.identifier.doi | 10.1002/bmc.70147 | |
| dc.identifier.issn | 02693879 | |
| dc.identifier.issue | 7 | |
| dc.identifier.pmid | 40522099 | |
| dc.identifier.scopus | 2-s2.0-105008080161 | |
| dc.identifier.scopusquality | Q3 | |
| dc.identifier.uri | https://hdl.handle.net/11494/5597 | |
| dc.identifier.volume | 39 | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.institutionauthor | Durmaz, Alper | |
| dc.language.iso | en | |
| dc.publisher | John Wiley and Sons Ltd | |
| dc.relation.ispartof | Biomedical Chromatography | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/embargoedAccess | |
| dc.subject | Antioxidant activity | |
| dc.subject | GC–MS | |
| dc.subject | Heliotropium sibiricum | |
| dc.subject | Molecular docking | |
| dc.subject | Phytochemical analysis | |
| dc.title | Phytochemical analysis, radical scavenging activity, and molecular docking studies of heliotropium sibiricum (L.) J.I.M.melo | |
| dc.type | Article |
