Effects of black hoof medicinal mushroom, phellinus linteus (Agaricomycetes), polysaccharide extract in streptozotocin-induced diabetic rats

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dc.authorid0000-0002-7262-0036en_US
dc.authoridTR53436en_US
dc.contributor.authorYamaç, Mustafa
dc.contributor.authorZeytinoglu, Melih
dc.contributor.authorŞentürk, Hakan
dc.contributor.authorKartkaya, Kazım
dc.contributor.authorKanbak, Güngör
dc.contributor.authorBayramoğlu, Gökhan
dc.contributor.authorOğlakçı, Ayşegül
dc.contributor.authorVan Griensven, Leo J. L. D.
dc.date.accessioned2020-11-09T10:41:10Z
dc.date.available2020-11-09T10:41:10Z
dc.date.issued2016
dc.departmentAÇÜ, Artvin Meslek Yüksekokuluen_US
dc.description.abstractIn this article we report the healing effects of a Phellinus linteus fruiting body hot water extract (PLE) in streptozotocin (STZ)?induced diabetic rats. PLE was given before and after STZ. The preprotective, protective, and postprotective effects of PLE on STZ-induced oxidative stress were studied using biochemical (caspase 3 activity, cytosolic-to-lysosomal ratio of cathepsin B and L, DNA fragmentation levels), ordinary histological and immuno-histochemical investigation parameters. Following oral administration of PLE after STZ application, the serum glucose concentration significantly decreased up to 41.13% compared with the control group (P < 0.05). The hypoglycemic potential of the PLE was further supported by an increase of insulin secretion in the islets of Langerhans. In addition, the number of cells in Langerhans islets increased by 45.89% when PLE was given after STZ application. On the other hand, the use of PLE before oxidative stress could not prevent the onset of diabetes. This is, to our knowledge, the first study of the effect of application time of orally administered Ph. Linteus hot water extract on STZ-induced diabetes.
dc.identifier.citationYamaç, M., Zeytinoğlu, M., Şentürk, H., Kartkaya, K., Kanbak, G., Bayramoğlu, G., ... & Van Griensven, L. J. L. D. (2016). Effects of black hoof medicinal mushroom, Phellinus linteus (Agaricomycetes), polysaccharide extract in streptozotocin-induced diabetic rats. International journal of medicinal mushrooms, 18(4), 301-311.en_US
dc.identifier.doi10.1615/IntJMedMushrooms.v18.i4.30
dc.identifier.endpage311en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage301en_US
dc.identifier.urihttps://hdl.handle.net/11494/2431
dc.identifier.volume28en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBayramoğlu, Gökhan
dc.language.isoenen_US
dc.publisherBegell Houseen_US
dc.relation.ispartofInternational Journal of Medicinal Mushrooms
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntidiabetic activityen_US
dc.subjectMedicinal mushroomsen_US
dc.subjectPhellinus linteusen_US
dc.subjectPolysaccharideen_US
dc.subjectRaten_US
dc.titleEffects of black hoof medicinal mushroom, phellinus linteus (Agaricomycetes), polysaccharide extract in streptozotocin-induced diabetic ratsen_US
dc.typeArticle

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