Antioxidant, antimicrobial, anticancer, and molecular docking insights into pancratium maritimum seeds and flowers: A phytochemical approach

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dc.contributor.authorErtuğrul, Muhammed Sait
dc.contributor.authorBalpınar, Özge
dc.contributor.authorAytar, Erdi Can
dc.contributor.authorAydın, Betül
dc.contributor.authorİncilay Torunoglu, Emine
dc.contributor.authorDurmaz, Alper
dc.contributor.authorRossato Viana, Altevir
dc.date.accessioned2025-03-19T10:59:43Z
dc.date.available2025-03-19T10:59:43Z
dc.date.issued2025
dc.departmentAÇÜ
dc.description.abstractThis study investigates the antioxidant, antimicrobial, and anticancer properties of Pancratium maritimum L. in Sp. Pl.: 291 (1753) seeds and flowers. Antioxidant activity was assessed using DPPH free radical scavenging and iron chelation assays. Antimicrobial evaluations assessed the efficacy of the extracts against diverse microorganisms. Cell viability assays were conducted on the dukes c colon cancer (SW480), while gas chromatography-mass spectrometry (GC-MS) analysis facilitated the identification of bioactive compounds. The ethanol extract of P. maritimum seeds exhibited a total phenolic content of 296.89±14.53 mg GAE/g extract DW and a total flavonoid content of 361.03±20.18 mg QE/g extract DW. Conversely, the flower extract showed a total phenolic content of 95.03±7.22 mg GAE/g extract DW and a total flavonoid content of 272.12±16.42 mg QE/g extract DW. As a result, the ethanol extract of P. maritimum seeds contains higher phenolic and flavonoid contents than the flower extract. Antimicrobial evaluations demonstrated significant inhibitory effects of both seed and flower extracts, with minimum inhibitory concentration (MIC) values ranging from 25 to >50 mg/mL. Notably, the seed extract showed greater activity against E. coli and C. krusei. GC-MS analysis identified 18 bioactive compounds in the seed extract and 16 in the flower extract, with crucial components including ethyl oleate and 5-hydroxymethylfurfural. Additionally, cell viability assays revealed that ethanol extracts from seeds and flowers significantly reduced SW480 cell viability, particularly at doses of 750 μg/mL and 250 μg/mL, respectively. These findings underscore the therapeutic potential of P. maritimum in terms of its antioxidant, antimicrobial, and anticancer properties, highlighting its value as a natural source of antioxidants and antimicrobial agents. Furthermore, the molecular docking study emphasises strong binding interactions of key compounds, particularly ethyl oleate and hexadecanoic acid ethyl ester, with the human STARD10 protein. The biological interactions and health implications of P. maritimum provide a significant foundation for future research in drug development and therapeutic applications.
dc.identifier.doi10.1002/open.202400407
dc.identifier.issn21911363
dc.identifier.issue2
dc.identifier.pmid39790022
dc.identifier.scopus2-s2.0-85214514447
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/11494/5455
dc.identifier.volume14
dc.identifier.wosWOS:001394745000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofChemistryOpen
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntioxidant activity
dc.subjectGC-MS analysis
dc.subjectMolecular docking
dc.subjectPancratium maritimum
dc.subjectSTARD10 protein
dc.subjectSW480 cell line
dc.titleAntioxidant, antimicrobial, anticancer, and molecular docking insights into pancratium maritimum seeds and flowers: A phytochemical approach
dc.typeArticle

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